Associations: The risk of chromosomal abnormalities, especially trisomy 18, is about 1-2% when no other anomalies are present and the risk increases to about 1 in 3 if any other associated abnormalities are detected antenatally. The risk of Down’s syndrome in fetuses with CPC but no other anomalies detected antenatally is 1 in 880, nearly the same as in the general population. Furthermore, isolated choroid plexus cyst in women of <35 years of age may not increase the risk of trisomy 18.
Management: A careful search for associated anomalies is indicated. If an additional sonomarker including hands is identified, karyotyping should be performed. Isolated CPCs do not alter standard obstetric management.
Prognosis: Good and usually asymptomatic and transient for isolated CPCs, though persistent enlarged CPC need follow-up or even neurosurgical intervention in some cases.
Recurrence risk: Sporadic.