Parameth Thiennimitr, M.D.,Ph.D.

Associate professor

E-mail

parameth.t@cmu.ac.th

Office

50th Anniversary building, Room 718, Faculty of Medicine

Research interest

Dr. Parameth’s lab is interested in how the interaction between host immune system, gut microbiota, and pathogenic bacteria (Salmonella enterica Typhimurium and uropathogenic Escherichia coli) shaping outcomes of the infection. Interventions for non-typhoidal salmonellosis (NTS) and bacterial urinary tract infection (UTI) such as probiotic or bacteriophage therapy are also the research focuses in my lab. By using the bacterial genetics approaches, cell culture and mouse models of NTS and UTI, we are aiming to answer the fundamental research questions important for human health.

Short biography

Dr. Parameth got his M.D. degree from Naresuan University in 2004 and his Ph.D. in Microbiology from University of California Davis (UCD), US in 2012. During his study in Andreas J. Baumler’s lab at the Department of Medical Microbiology and Immunology at UCD, he discovered that the Gram negative bacterium Salmonella enterica Typhimurium (STM) can thrive in the inflamed gut by using tetrathionate as an alternative electron acceptor to breakdown ethanolamine, a non-fermentable molecule, availabe in gut. (published in Proc Natl Acad Sci USA. 2011 Oct 18;108(42), PMID 21969563 and Nature. 2010 Sep 23;467(7314) PMID 20864996). Then, he was a postdoctoral fellow in Dr. Michael H Hsieh’s Lab at Stanford University, Palo Alto, US during year 2013-2014. He was investigated the role of bacterial metabolism in urinary tract infection (UTI). Dr. Parameth became an Assistant Professor at the Department of Microbiology MED CMU in 2015. Dr. Parameth’s lab at MED CMU is now focusing on the interventions (probiotic, prebiotic, bacteriophage) in acute non-typhoidal salmonellosis and bacterial UTI by using bacterial genetic approaches, cell cultures and mouse models of infection.

Field of research

Host-microbe interactions, Immunity to infection, Gut microbiota in infectious diseases

Current projects

Host-microbe interplay in salmonellosis and urinary tract infection. Interventions in NTS and UTI.

Scopus publications