Somdet Srichairatanakool
ศ.ดร.สมเดช ศรีชัยรัตนกูล

Position Professor

EMail ssrichai@med.cmu.ac.th

 

 

 

Education

  • 2000        University of London, United Kingdom    London
  • 1989        Mahidol University    Thailand
  • 1983        Chiang Mai University    Thailand

 

Research Interests

  1. Iron overload and oxidative stress in thalassemia
  2. Iron metabolism and chelation in cells and animals
  3. Free radicals and anti-oxidants
  4. Biochemistry of malaria parasites

 

Publications

  • 1987    Rangdaeng, S., Scollard, D.M., Srichairatanakool, S., Suttachit, M. and Phonphutkul, C. (1987). Glycogen storage disease type II (Pompes disease): the first biochemical evidence in Thailand. J. Med. Assoc. Thai. 70(9): 536-542.
  • 1996    Olivieri, N.F., Nisbet-Brown, E., Srichairatanakool, S., Dragsten, P., Hallaway, P., Hedlund, B. and Porter, J.B. (1996). Studies of iron excretion and non-transferrin-bound plasma iron (NTBPI) following a single infusion of hydroxyethyl starch-deferoxamine (HES-DFO): A new approach to iron chelation therapy. Blood. 90(10) Supplement 1(part 1), 301a.
  • 1997    Perry, A.R., Srichairatanakool, S., McKeag, N., Peniket, A.J., Goldstone, A.H. and Porter, J.B. (1997). Non-transferrin-bound iron (NTBI) persisting in the long-term after bone marrow transplantation (BMT). Bone Marrow Transplant. 19(Supplement S7), 24.
  • 1997    Bradley, S.J., Gosriwatana, I., Srichairatanakool, S., Hider, R.C. and Porter, J.B. (1997). Non-transferrin-bound iron induced my myeloablative chemotherapy. Br. J. Haematol. 99: 337-343.
  • 1998    Porter, J.B., Srichairatanakool, S., Nathan, D.G., Schinkel, H., Gee, B. and Porter, J.B. (1998). Relative efficacy of subcutaneous infusions and bolus injections of deferoxamine in the removal of non-transferrin-bound iron (NTBI). Blood, 92(10) Supplement 1(part 1), 668a.
  • 1999    Wickramasinghe, S.N., Thein, S.L., Srichairatanakool, S. and Porter, J.B. (1999). Determinants of iron status and bilirubin levels in congenital dyserythropoietic anaemia type I. Br. J. Haematol. 107: 522-525.
  • 2004    Vip Viprakasit, Alison T. Merryweather-Clarke, Yingyong Chinthammitr, Lisa Schimanski, Hal Drakesmith, Somdet Srichairatanakool, Chanin Limwongse, Alain Townsend, Kathryn J.H. Robson. (2004) Molecular Diagnosis of the First Ferroportin Mutation (C326Y) in the Far East Causing a Dominant Form of Inherited Iron Overload. Blood, 104(11), Supplement 3027
  • 2004    Seenumgoen S, Mahanupab P, Srichairatanakool S and Chiewchanvit S. (2004) Ochronosis: A Case Report and Review of the Literature. Thai J. Dematol. 20(2): 90-102.
  • 2005    Porter JB, Rafique R, Srichairatanakool S, Davis BA, Shah FT, Hair T and Evans P. (2005) Recent insights into interactions of deferoxamine with cellular and plasma iron pools: implications for clinical use. Ann. N.Y. Acad. Sci. 1054: 155-168
  • 2005    Nattakaan Leelarungrayab, Viboon Rattanapanone, Somdet Srichairatanakool, Nantaya Chanarat and Janusz M. Gebicki. (2005) Anti-Oxidative Stress and Anti-Inflammatory Effects of Thai Shallot (Allium Ascalonicum L.) Extracts in Human Monocytic (U937) Cells. Niigata J. Health
  • 2006    Somdet Srichairatanakool, Sakaewan Ounjiajean, Chonthida Thephinlap, Udompun Khansuwan, Chada Phisalpong and Suthat Fucharoen. (2006) IRON-CHELATING AND FREE-RADICAL SCAVENGING ACTIVITIES OF MICROWAVE-PROCESSED GREEN TEA IN IRON OVERLOAD. Hemoglobin, 30(2): 311-327.
  • 2007    Tanat Incharoen, Chontida Tephinlap, Somdet Srichairatanakool, Siriporn Chattipakorn, Pranee Winichagoon, Suthat Fucharoen, Jim Vadolas and Nipon Chattipakorn. (2007) Heart Rate Variability in beta-Thalassemia Mice. Int. J. Cardiol. 121(2): 203-204.
  • 2007    C. Thephinlap, S. Ounjaijean, U. Khansuwan, S. Fucharoen, J.B. Porter and S. Srichairatanakool. (2007) Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress. Med. Chem. 3(3):289-296.
  • 2007    S. Srichairatanakool, C. Thephinlap, C. Phisalaphong, J.B. Porter and S. Fucharoen. (2007) Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. Curr. Med. Chem. 3:469-474.
  • 2007    Duangruthai Phongchiewboon, Jeerawan Wannaweke, Prasong Tienboon, Pannee Siriwatanapa, Kannika Vitsupakorn, Somdet Srichairatanakool, Aram Phongchiewboon. (2007) Serum and breast-milk vitamin A levels in nursing women in three selected districts of Chiang Mai Province of Thailand. Thai J. Clin. Nutri. 1(2): xxx-xxx.
  • 2008    Meerang, M., Nair, J., Sirankapracha, P., Thephinlap, C., Srichairatanakool, S., Fucharoen, S., Bartsch, H. (2008) Increased urinary 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine excretion in thalassemia patients: markers for lipid peroxidation-induced DNA damage. Free Radic. Biol. Med. 44(10): 1863-1868. (IF = 4.971)
  • 2008    Ounjaijean, S., Thephinlap, C., Khansuwan, U., Phisalapong, C., Fucharoen, S., Porter, J. B., Srichairatanakool, S. (2008) Effect of green tea on iron status and oxidative stress in iron-loaded rats Med Chem. 4(4): 365-370. (IF = 1.468)
  • 2009    Winthana Kusirisin, Somdet Srichairatanakool, Peerasak Lerttrakarnnon, Narissara Lailerd, Maitree Suttajit, Churdsak Jaikang and Chaiyavat Chaiyasut. (2009) Antioxidative Activity, Polyphenolic Content and Anti-Glycation Effect of Some Thai Medicinal Plants Traditionally Used in Diabetic Patients. Med. Chem. 5(2): 139-147. (IF = 1.468)
  • 2009    Lok, C. Y., Merryweather-Clarke, A. T., Viprakasit, V., Chinthammitr, Y., Srichairatanakool, S., Limwongse, C., Oleesky, D., Robins, A. J., Hudson, J., Wai, P., Premawardhena, A., de Silva, H. J., Dassanayake, A., McKeown, C., Jackson, M., Gama, R., Khan, N., Newman, W., Banait, G., Chilton, A., Wilson-Morkeh, I., Weatherall, D. J., Robson, K. J. (2009) Iron overload in the Asian community. Blood. 114(1): 20-25. (IF 2009 = 10.555)
  • 2009    Meerang, M., Nair, J., Sirankapracha, P., Thephinlap, C., Srichairatanakool, S., Arab, K., Kalpravidh, R., Vadolas, J., Fucharoen, S., Bartsch, H. (2009) Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: Comparison with levels in the lymphocytes of thalassemia patients. Int. J. Cancer, 125(4): 759-766. (IF 2009 = 4.722)
  • 2009    Thephinlap, C., Phisalaphong, C., Fucharoen, S., Porter, J.B., Srichairatanakool, S*. (2009) Efficacy of Curcuminoids in Alleviation of Iron overload and Lipid Peroxidation in Thalassemic Mice. Med. Chem. 5(5): 474-482. (IF 2009 = 1.642)
  • 2009    Rutjanaprom, W., Kanlop, N., Charoenkwan, P., Sittiwangkul, R., Srichairatanakool, S., Tantiworawit, A., Phrommintikul, A., Chattipakorn, S., Fucharoen, S. and Chattipakorn, N. (2009) Heart rate variability in beta-thalassemia patients. Eur. J. Haematol. 83(5): 483-489. (IF 2009 = 2.345)
  • 2009    Kalpravidh, R.W., Siritanaratkul, N., Insain, P., Charoensakdi, R., Panichkul, N., Hatairaktham, S., Srichairatanakool, S., Phisalaphong, C., Rachmilewitz, E. Fucharoen, S. (2009) Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids. Clin. Biochem. 43(4-5): 424-429. (IF 2009 = 2.019)
  • 2009    Chattipakorn, N., Settakorn, J., Petsophonsakul, P., Suwannahoi, P., Mahakranukrauh, P., Srichairatanakool, S., Chattipakorn, S. C. (2009) Cardiac mortality is associated with low levels of omega-3 and omega-6 fatty acids in the heart of cadavers with a history of coronary heart disease. Nutr Res. 29(10): 696-704. (IF 2009 = 1.197
  • 2010    Saewong, T., Ounjaijean, S., Mundee, Y., Pattanapanyasat, K., Fucharoen, S., Porter, J. B., Srichairatanakool, S*. (2010) Effects of Green Tea on Iron Accumulation and Oxidative Stress in Livers of Iron-Challenged Thalassemic Mice. Med. Chem. 6(2): 57-64. (IF 2009 = 1.642)
  • 2010    Kumfu, S., Chattipakorn, S., Srichairatanakool, S., Settakorn, J., Fucharoen, S., Chattipakorn, N.* (2010) T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice. Eur. J. Haematol. 86(2): 156-166. (IF 2009 = 2.345)
  • 2011    Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J.B. and Srichairatanakool, S.* (2011) Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids. Med. Chem. 7(1): 62-69. (IF 2009 = 1.642)
  • 2011    Tipsuwan, W., Srichairatanakool, S., Kamchonwongpaisan, S., Yuthavong, Y. and Uthaipibull, C.* (2011) Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model. Malaria. J. 10: 119. (IF 2009 = 3.002)
  • 2011    Bhoopat, L.*, Srichairatanakool, S., Kanjanapothi, D., Taesotikul, T. Thananchai, H. and Bhoopat, T. (2011) Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities. J. Ethnopharmacol. 136(1): 55-66. (IF 2009 = 2.322)
  • 2011    Ounjaijean, S.*, Westermarck, T., Partinen, M., Plonka-Poltorak, E., Kaipainen, P., Kaski, M., Fucharoen, S., Srichairatanakool, S. and Atroshi, F. (2011) Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. Int. J. Clin. Pharmacol. Ther. 49(4): 268-276. (IF 2009 = 1.381)
  • 2011    Chaiyasut, C., Kusirisin, W., Lailerd, N., Lerttrakarnnon, P., Suttajit, M. and Srichairatanakool, S.* (2011) Effects of phenolic compounds of fermented Thai indigenous plants on oxidative stress in streptozotocin-induced diabetic rats. Evid. Based Complement. Alternat. Med. 2011: 749307. (IF 2009 = 2.064)
  • 2011    Somsak, V., Srichairatanakool, S., Kamchonwongpaisan, S., Yuthavong, Y. and Uthaipibull, C.* (2011) Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment. Mol. Biochem. Parasitol. 177(2): 156-159. (IF 2009 = 2.939)
  • 2011    Voravuth Somsak, Chairat Uthaipibull*, Parichat Prommana, Somdet Srichairatanakool, Yongyuth Yuthavong and Sumalee Kamchonwongpaisan. (2011) Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening. Malaria J. 10: 291. (IF 2009 = 3.002)
  • 2011    Wachiraporn Tipsuwan, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong and Chairat Uthaipibull*. (2011) Identification of Pfdhfr mutant variants in Plasmodium berghei model. Maejo Inl. J. Sci. Technol. 5(03): 401-412. (IF 2009 = 0.222)
  • 2011    Wachiraporn Tipsuwan, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong and Chairat Uthaipibull*. (2011) Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model. Malaria J. 10: 119. (IF 2009 = 3.002)
  • 2011    Patcharaporn Paokanta, Napat Harnpornchai, Somdet Srichairatanakool, and Michele Ceccarelli. (2011) The Knowledge Discovery of ฮฒ-Thalassemia Using Principal Components Analysis: PCA and Machine Learning Techniques. Int. J. e-Education, e-Business, e-Management and e-Learning. 1(2): 169-174.
  • 2012    S Teekachunhatean, N Tosri, C Sangdee, R Wongpoomchai, W Ruangyuttikarn, C Puaninta and S Srichairatanakool*. (2012) Antioxidant Effects after Coffee Enema or Oral Coffee Consumption in Healthy Thai Male Volunteers. Human Exp Toxicol. 31(7): 643-651. (IF 2009 = 1.3037)
  • 2012    Voravuth Somsak, Somdet Srichairatanakool, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan, Chairat Uthaipibull*. (2012) Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I. Acta Tropica. 122: 113โโ‚ฌโ€œ 118. (IF 2009 = 2.221)
  • 2012    Patcharaporn Paokanta, Michele Ceccarelli, Napat Harnpornchai, Nopasit Chakpitak and Somdet Srichairatanakool. (2012) Rule Induction for Screening Thalassemia Using Machine Learning Techniques: C5.0 and CART. ICIC Express Letters. 6(2): 301-306.
  • 2013    Patcharaporn Paokanta, Napat Harnpornchai, Nopasit Chakpitak, Somdet Srichairatanakool and Michele Ceccarelli. (2013) KNOWLEDGE AND DATA ENGINEERING: FUZZY APPROACH AND GENETIC ALGORITHMS FOR CLUSTERING b-THALASSEMIA OF KNOWLEDGE BASED DIAGNOSIS DECISION SUPPORT SYSTEM. ICIC Express Letters. 7(1): C2012-851.
  • 2013    Kanjana Pangjit, Ratana Banjerdpongchai, Chada Phisalaphong, Suthat Fucharoen and Somdet Srichairatanakool*. (2013) Efficacy of 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) in treatment of iron-loaded hepatocyte cultures. Adv Biosci Biotec. (In press). (IF = 1.778 subjected to ISI confirmation report. p://www.scirp.org/images ForEmail/abstract/ISL)

 

Graduate Students (as a major advisor)