Jittasak Khowsathit, Ph.D.
อ.ดร.จิตศักดิ์ โค้วสถิตย์
Position: Lecturer
Telephone: +66-53-934437 ext 222
E-Mail: jittasak.khowsathit@cmu.ac.th or jkhowsathit@gmail.com
LinkedIn: jkhowsathit
Education
2019 Ph.D. (Biochemistry and Biophysics), University of Kansas, Lawrence KS, USA
2011 B.S. (Biochemistry), Chulalongkorn University, Thailand
Training Fellowships
2019 – 2022 Postdoctoral Associate, Fox Chase Cancer Center (Dept. of Molecular Therapeutics), Philadelphia PA, USA
Research Interests
- Computational chemical biology
- Protein design
- Antibody engineering
- Protein/small-molecule interaction
- In silico drug discovery
Publications
- Post SJ, Keohane CE, Rossiter LM, Kaplan AR, Khowsathit J, Matuska K, Karanicolas J, Wuest WM. Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase. ACS Infect Dis. 6, p.1372-1377 (2020).
- Khowsathit J, Bazzoli A, Cheng H, Karanicolas J. Computational Design of an Allosteric Antibody Switch by Deletion and Rescue of a Complex Structural Constellation. ACS Cent Sci. 6, p. 390-403 (2020).
- Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 175, p. 1244-1258 (2018).
- Kaiser CE, Rincon Pabon JP, Khowsathit J, Castaldi MP, Kazmirski SL, Weis DD, Zhang AX, Karanicolas J. Modulating Antibody Structure and Function through Directed Mutations and Chemical Rescue. ACS Synth Biol. 7, p. 1152-62 (2018).
- Keohane CE, Steele AD, Fetzer C, Khowsathit J, Van Tyne D, Moynié L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM. Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. J Am Chem Soc. 140, p. 1774-1782 (2018).
- Gowthaman R, Miller SA, Rogers S, Khowsathit J, Lan L, Bai N, Johnson DK, Liu C, Xu L, Anbanandam A, Aubé J, Roy A, Karanicolas J. DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J Med Chem. 59, p. 4152‑70 (2016).
Patents
- Karanicolas J, Khowsathit J, Yeggoni D. Compositions and Methods for Modulation of Antibody Activity. US 20220175918, Fox Chase Cancer Center, 9 June 2022.
Scholarship & Awards
- 2006 – 2011 Junior Science Talent Project (JSTP) Scholarship, NSTDA, Thailand