Arisa (Imsumran) Bonness
ผศ.ดร.อริสา (อิ่มสำราญ) บอนเนซซ์

Position Assistant Professor

Telephone 053-934436 Ext 216

Fax 053-894031

Email arisa.bonness@cmu.ac.th

 

 

Education

  • 2007        Doctor of Philosophy (Medical Science), Sapporo Medical University, Japan
  • 1997        Master of Science (Biochemistry), Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
  • 1993        Bachelor of Science (Biochemistry and Biochemical Technology), Chiang Mai University, Thailand

 

Professional Experience

  • 1997    Lecturer
  • 2017    Assistant Professor

 

Research Interests

  1. Biochemistry of Obesity, Diabetes and Cancer
  2. Insulin and Insulin like growth factor in Diabetes and Cancer
  3. Natural plant products as potential anti-obesity, anti-diabetic, anti-cancer agents

 

Scholarship & Awards

  • 1994    ทุนอุดหนุนการศึกษา ภาควิชาชีวเคมี คณะแพทยศาสตร์ศิริราชพยาบาล มหาวิทยาลัยมหิดล
  • 1996    ทุนสนับสนุนการวิจัย สำหรับนักศึกษาระดับบัณฑิตศึกษา สำนักงานคณะกรรมการวิจัยแห่งชาติ
  • 1996    FAOBMB Travel fellowship จาก Federation of Asian and Ocenian Biochemists and Molecular Biologist Inc.
  • 2003    Ph.D. Scholarship จาก Department of Internal Medicine (I), Sapporo Medical University, Japan
  • 2014    Best Poster Presentation Award จาก The 8th Thailand Congress of Nutrition
  • 2019    Visiting Associate Professor, Graduate School of Medical Sciences, Kumamoto University, Japan (Nov 2019 – Mar 2024)

Publications

  • 1999    Lertrit P, Ruangvaravate N, Trongpanich Y, Imsumran A, Mungkornkarn C, Neungton N. Lebers hereditary optic neuropathy (LHON) with mitochondrial ND4 gene mutation (11778) in a Thai patient. J Med Assoc Thai. 1999 Jan;82(1):59-64.
  • 1999    Lertrit P, Imsumran A, Karnkirawattana P, Devahasdin V, Sangruchi T, Atchaneeyasakul L, Mungkornkarn C, Neungton N. A unique 3.5-kb deletion of the mitochondrial genome in Thai patients with Kearns-Sayre syndrome. Hum Genet. 1999 Jul-Aug;105(1-2):127-31.
  • 2002    Yamamoto H, Min Y, Itoh F, Imsumran A, Horiuchi S, Yoshida M, Iku S, Fukushima H, Imai K. Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability. Genes Chromosomes Cancer. 2002 Mar;33(3):322-5.
  • 2002    Yamamoto H, Imsumran A, Fukushima H, Adachi Y, Min Y, Iku S, Horiuchi S, Yoshida M, Shimada K, Sasaki S, Itoh F, Endo T, Imai K. Analysis of gene expression in human colorectal cancer tissues by cDNA array. J Gastroenterol. 2002 Nov;37 Suppl 14:83-6.
  • 2003    Yamamoto H, Iku S, Adachi Y, Imsumran A, Taniguchi H, Nosho K, Min Y, Horiuchi S, Yoshida M, Itoh F, Imai K. Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer. J Pathol. 2003 Feb;199(2):176-84.
  • 2004    Yamamoto H, Vinitketkumnuen A, Adachi Y, Taniguchi H, Hirata T, Miyamoto N, Nosho K, Imsumran A, Fujita M, Hosokawa M, Hinoda Y, Imai K. Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma. Carcinogenesis. 2004 Dec;25(12):2353-60.
  • 2005    Min Y, Adachi Y, Yamamoto H, Imsumran A, Arimura Y, Endo T, Hinoda Y, Lee CT, Nadaf S, Carbone DP, Imai K. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut. 2005 May;54(5):591-600.
  • 2007    Lee YJ, Imsumran A, Park MY, Kwon SY, Yoon HI, Lee JH, Yoo CG, Kim YW, Han SK, Shim YS, Piao W, Yamamoto H, Adachi Y, Carbone DP, Lee CT. Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity of lung cancer cell lines by blocking IGF-1 pathway. Lung Cancer. 2007 Mar;55(3):279-86.
  • 2007    Imsumran A, Adachi Y, Yamamoto H, Li R, Wang Y, Min Y, Piao W, Nosho K, Arimura Y, Shinomura Y, Hosokawa M, Lee CT, Carbone DP, Imai K. Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma. Carcinogenesis. 2007 May;28(5):947-56.
  • 2008    Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther. 2008 Jun;7(6):1483-93.
  • 2009    Adachi Y, Li R, Yamamoto H, Min Y, Piao W, Wang Y, Imsumran A, Li H, Arimura Y, Lee CT, Imai K, Carbone DP, Shinomura Y. Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin. Carcinogenesis. 2009;30(8):1305-13.
  • 2010    Wang Y, Adachi Y, Imsumran A, Yamamoto H, Piao W, Li H, Ii M, Arimura Y, Park MY, Kim D, Lee CT, Carbone DP, Imai K, Shinomura Y. Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers. J Gastroenterol. 2010;45(2):159-70.
  • 2010    Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, Pompimon W, Lee TR. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. 2010;13(6):1347-54.
  • 2014    Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y. The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma. Tumour Biol. 2014 Feb;35(2):973-85.
  • 2017    Budluang P, Pitchakarn P, Ting P, Temviriyanukul P, Wongnoppawich A, Imsumran A. Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus. Food Sci Nutr. 2017 Aug;5(3):486-96.
  • 2018    Kaewtunjai N, Wongpoomchai R, Imsumran A, Pompimon W, Athipornchai A, Suksamrarn A, Lee T, Tuntiwechapikul W. Ginger Extract Promotes Telomere Shortening and Cellular Senescence in A549 Lung Cancer Cells. ACS Omega. 2018;3:18572-81.
  • 2020    Dukaew N, Chairatvit K, Pitchakarn P, Imsumran A, Karinchai J, Tuntiwechapikul W, Wongnoppavich A. Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncology Reports.2020; 44:1441-1454. 2020 JIF : 3.041; Q2 cited: 2-year=3/all=3
  • 2021    Sakuludomkan W, Yeewa R, Subhawa S, Khanaree C, Bonness A I, Chewonarin T. Effects of fermented Houttuynia cordata thunb. on diabetic rats induced by a high-fat diet with streptozotocin and on insulin resistance in 3t3-l1 adipocytes. J Nutri and Met. 2021. 2021 cited: 2-year=1/all=1
  • 2021    Karinchai J, Budluang P, Temviriyanukul P, Ting P, Nuchuchua O, Wongnoppavich A, Imsumran A, Pitchakarn P. Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7. cells J Ethnopharm. 280. 2021 JIF : 3.690; Q1 cited: 2-year=2/all=2
  • 2023    Buacheen P., Chaipuang A., Karinchai J., Nuchuchua O., Imsumran A., Wongnoppavich A., Pimpha N., Pitchakarn P. Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using Anoectochilus burmannicus Extract as a Potential Novel Functional Ingredient Nutrients. 15. 2023 JIF : 6.706; Q1
  • 2023  Buacheen P., Karinchai J., Kammasit N., Temviriyanukul P., Butkinaree C., Watthana S., Wongnoppavich A., Imsumran A., Pitchakarn P. Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A Scientific Reports. 13. 2023 JIF : 4.997; Q2
  • 2023  Lailerd, M.; Linn, T. W.; Lailerd, N.; Amornlerdpison, D.; Imsumran, A. Assessment of Antidiabetic and Anti-Inflammatory Activities of Carissa Carandas Linn Extract: In Vitro and in Vivo Study. Appl. Sci. (Basel) 2023, 13 (11), 6454. JIF : 2.838; Q2
  • 2023  Nuchuchua, O.; Inpan, R.; Srinuanchai, W.; Karinchai, J.; Pitchakarn, P.; Wongnoppavich, A.; Imsumran, A. Phytosome Supplements for Delivering Gymnema Inodorum Phytonutrients to Prevent Inflammation in Macrophages and Insulin Resistance in Adipocytes. Foods 2023, 12 (11). JIF : 5.561; Q1

 

Proceeding

  • 2014.    Waloh N, Wongnoppavich A, Bonness A. Effects of purple rice (Oryza sativa L.) on adipogenesis and inflammation-induced insulin resistance in adipocyte. The 4th International Biochemistry and Molecular Biology Conference 2014 ‘Bridging ASEAN Biochemical Research Communities’ April 2-3, 2014, Rama Gardens Hotel, Thailand
  • 2014.    Waloh N, Bonness A, Wongnoppavich A. Inhibitory effects of Azadirachta indica leaf ethanolic extract on inflammation in macrophage and insulin resistance in adipocyte. The 4th International Biochemistry and Molecular Biology Conference 2014 ‘Bridging ASEAN Biochemical Research Communities’ April 2-3, 2014, Rama Gardens Hotel, Thailand
  • 2014.    Kaewprasert P, Waloh N, Wongnoppavich A, Bonness A. In vitro anti-inflammatory and anti-insulin resistant activities of Solanum torvum and Solanum trilobatum fruit Ethanolic extracts. The 4th International Biochemistry and Molecular Biology Conference 2014 ‘Bridging ASEAN Biochemical Research Communities’ April 2-3, 2014, Rama Gardens Hotel, Thailand
  • 2018.    Rodthayoy D, Karinchai J, Dukaew N, Buacheen P, Wongnoppavich A, (Imsumran) Bonness A, Khantamat O, Chantarasuwan B, Temviriyanukul P, Pitchakarn P. Effect of Ficus dubia latex and root extracts in lipopolysaccharide-induced macrophages. 1st Innovation of Functional Foods in Asia (IFFA 2018) Jan 22-24, 2018; Phayao University, Payao, Thailand
  • 2018.    Buacheen P, Pitchakarn P, Wongnoppavich A, Imsumran Bonness A. Coffee pulp ethanolic extract ameliorates palmitic acid-induced
    inflammation in RAW 264.7 macrophage and insulin resistance in 3T3-L1 adipocyte. The 6th International Biochemistry and Molecular Biology Conference 2018 “Networking in Molecular Biosciences towards Creativity and Innovation” June 20-22, 2018, Rayong Resort, Rayong, Thailand
  • 2019.    Karinchai J, Budluang P, Rodthayoy D,  Kaewtunjai N, Nuchuchua O, Temviriyanukul P, Wongnoppavich A, (Imsumran) Bonness A, Pitchakarn P. Anti-inflammatory effects of the hydrophilic fractions of Anoectochilus burmanicus. The 35th International Annual Meeting in Pharmaceutical Sciences and CUMPU International Collaborative Research Conference, March 8, 2019, Eastin Hotel (Makkasan), Bangkok, Thailand.
  • 2020.    Yodweerapong T, Buacheen P, Kammasit N, Karichai J, Imsumran A, Wongnoppavich A, Chantarasuwan B, Temviriyanukul P, Pitchakarn P. Effect of Ficus dubia extract on adipogenesis. The 46th International Congress on Science, Technology and Technology-based Innovation (STT46), Ramkhamhaeng University, Bangkok, Thailand, Oct 5-7, 2020, pp 970-4.
    2020.    Kammasit N, Yodweerapong T, Buacheen P, Karichai J, Imsumran A, Wongnoppavich A, Temviriyanukul P, Pitchakarn P. Effect of Anoectochilus burmannicus aqueous extract on obesogens induced adipocyte transformation. The 46th International Congress on Science, Technology and Technology-based Innovation (STT46), Ramkhamhaeng University, Bangkok, Thailand, Oct 5-7, 2020, pp 975-81.
    2020.    Inpan R, Nuchuchua O, Srinuanchai W, Nooin R, Pitchakarn P, Wongnoppavich A, Imsumran A.: Nano-phytosome entrapping Gymnema inodorum extract for enhancing anti-inflammation in macrophage. The 46th International Congress on Science, Technology and Technology-based Innovation (STT46), Ramkhamhaeng University, Bangkok, Thailand, Oct 5-7, 2020, pp 992-9.
    2020.    Lailerd M, Lailerd N, Amornlerdpison D, Pitchakarn P, Wongnoppavich A, Imsumran A. Anti-inflammation and anti-insulin resistance activities of Carissa carandas Linn. Fruit extract. The 46th International Congress on Science, Technology and Technology-based Innovation (STT46), Ramkhamhaeng University, Bangkok, Thailand, Oct 5-7, 2020, pp 986-91.
  • 2022.    Jaiaree A, Karinchai J, Pitchakarn P, Wongnoppavich A, Imsumran A. Inhibitory effect of Carissa Carandas Linn. extract on adipogenesis and lipid accumulation of 3t3-l1 adipocyte. The 48th International Congress on Science, Technology and Technology-based Innovation (STT48), School of Science, Walailak University, Nakhon Si Thammarat, Thailand, Nov 29-Dec 1, 2022, pp 26-34.

 

Books

  1. ตำราชีวเคมีพื้นฐานสำหรับวิทยาศาตร์การแพทย์ เล่ม 1 คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่ 2558 พงษ์สวัสดิ์การพิมพ์ เชียงใหม่

 

Training Fellowships

  • 2001.    Visiting research fellowship จาก Department of Internal Medicine (I), Sapporo Medical University, Japan

 

Research Grants

  • 2012    Characterization of Biological Activities in Purple Rice on Inhibition of Adipogenesis and Insulin Resistance in Fat Cells    Agricultural Research Development Agency    Co-Investigator    785,500 Baht
  • 2012    Effect of Rice Bran Extracts on Adipocyte Differentiation and Anti-Insulin Resistance in Adipocytes    Medicine CMU Research Fund                         Principle Investigator    200,000 Baht
  • 2013    Anti-adipogenesis and Anti-insulin Resistant Activities of Five Thai Herbal Vegetables    National Research Council of Thailand    Co-Investigator     775,000 Baht
  • 2014    Biological Activities of Purple Rice on Inhibition of Lipid Accumulation and Anti-Insulin Resistance in Fat Cells    Medicine CMU Research Fund        Principle Investigator    200,000 Baht
  • 2014    Activity of Ethanolic Extracts from Coccinia Grandis, Solanum Torvum and Solunum Trilobatum on Inhibition of Insulin-resistance induced by inflammation    Medicine CMU Research Fund    Principle Investigator    200,000 Baht
  • 2014    Anti-insulin Resistance Effect of Purple Rice Extracts (Oryza sativa L. indica.) in Myotubes Induced by Macrophage Inflammation and Free Fatty Acids    National Research Council of Thailand    Principle Investigator    712,000 Baht
  • 2016    Activities of Coffee Pulp Aqueous Extract on Anti-Inflammation in Macrophage and Anti-Insulin Resistance in Adipocyte    Research and Researchers for Industries Project, Thailand Research Fund    Research Advisor    600,000 บาท
  • 2016    Activities of Anoectochilus burmannicus Extract on Anti-obesity and Anti-diabetes    Plant genetic conservation project under the royal initiative of her Royal Highness Princess Maha Chakri Sirindhorn    Principle Investigator    613,240 Baht
  • 2018    Effect of Coffee Pulp Ethanolic Extract on Anti-Inflammation in Macrophage and Anti-Insulin Resistance in Adipocyte    Faculty of Medicine Research Fund, Chiang Mai University    Principle Investigator    200,000 Baht
  • 2018    In vitro and in vivo Evaluation of Antidiabetic Activity of Carissa carandas Linn    Research and Researchers for Industries Project, Thailand Research Fund    Research Advisor    502,000 Baht
  • 2019    Anti-inflammation and anti-insulin resistance activities of Carissa carandas Linn Faculty of Medicine Research Fund, Chiang Mai University Principle Investigator 200,000 Baht
  • 2021    Effect of Carissa carandas Linn. extract on lipid accumulation of 3t3-l1 adipocyte Faculty of Medicine Research Fund, Chiang Mai University Principle Investigator 200,000 Baht
  • 2022    In vitro and in vivo studies of anti-diabetics activities of Thai fermented soybean, Fundamental Fund, Thailand Science Research and Innovation (TSRI) via Chiang Mai University, Principle Investigator, 700,000 Baht