Pimpisid Koonyosying

รศ. ดร.พิมพ์พิสิฐ   คุณยศยิ่ง

Position Associate Professor

Telephone 

Fax +6653894031

EMail pimpisid.k@cmu.ac.th

Affiliation Department of Biochemistry, Faculty of Medicine, Chiang Mai University

 

Education

  • 2018        Doctor of Philosophy (Biochemistry), Chiang Mai University, Thailand
  • 2011        Bachelor of Science (Medical Technology), Chiang Mai University, Thailand

 

Scholarship & Awards

2025               

The Erasmus+ staff mobility grant, the Medical University of Graz, Austria

2024               

Full scholarship on “Multi-Omics Short Course” by PMU-B, Thailand

2022 – 2023        

6-Month research on “ Effects of exogenous hepcidin on cellular iron and chelateable iron” at Red Cell Disorder Unit, Department of Haematology, University College London, London, United Kingdom, under Professor John B. Porter supervision and supported by UCL and Silence Therapeutics

2021               

Young Staff development scholarship, Thailand Research Fund.

2012 – 2018

The Royal Golden Jubilee (RGJ) PhD. Program 14 Scholarship, Thailand Research Fund.

2017

Student travel Bursary for Seventh Congress of the International BioIron Society (IBIS) at UCLA, Los Angles, California, USA

2016

Excellent Poster Presentation in RGJ PhD. Program, Thailand Research Fund, RGJ International Conference, Pattaya, Thailand.

2015

6-Month Research Collaboration UK Newton Fund-RGJ PhD. Program.

 

Publications

  1. Maneekesorn, S.; Choed-Amphai, C.;  Chanthong, S.;  Tantiworawit, A.;  Phusua, A.;  Paradee, N.;  Koonyosying, P.;  Srichairatanakool, S.; Charoenkwan, P., Oxidative stress and antioxidant capacity in hereditary elliptocytosis and hereditary pyropoikilocytosis. Br J Haematol 2026.
  2. Paradee, N.; Saengratwatchara, P.;  Srichairatanakool, S.; Koonyosying, P., Bombax ceiba flower extract enhances antioxidant defense and wound healing effects in human keratinocytes and fibroblasts. Pharm Biol 2026, 64 (1), 599-614.
  3. Maneekesorn, S.; Yingchutrakul, Y.;  Simanon, N.;  Kumsab, J.;  Butkinaree, C.;  Moonmuang, S.;  Li, J.;  Charoenkwan, P.;  Koonyosying, P.;  Paradee, N.;  Srichairatanakool, S.; Chuljerm, H., Therapeutic Potential of Deferiprone-Resveratrol Hybrid (DFP-RVT) Against Hepatic Iron Overload in beta-Thalassemia Mice: A Proteomic Analysis. Biomolecules 2026, 16 (2).
  4. Koonyosying, P.; Tharanon, W.;  Pairojthanachai, K.;  Samakarn, Y.;  Meejak, K.;  Paradee, N.;  Kerdto, O.;  Yubo, S.;  Zhong, Y.; Srichairatanakool, S., Green Tea Catechins Mitigate Hepatocyte Ferroptosis Through Attenuation of Oxidative Stress and Improvement of Antioxidant Systems. Antioxidants (Basel) 2025, 14 (12).
  5. Yampayon, K.; Sakares, W.;  Pitinanon, K.;  Limwongse, C.;  Srichairatanakool, S.;  Koonyosying, P.;  Sukasem, C.;  Triparn, K.;  Piriyapongsa, J.;  Ekwattanakit, S.;  Viprakasit, V.; Yodsurang, V., Pharmacogenomic and Clinical Predictors of Deferasirox Response in Transfusion-Dependent Thalassemia Identified Using Whole-Genome Sequencing. Clin Transl Sci 2025, 18 (12), e70441.
  6. Pokharel, B.; Tipsuwan, W.;  Pongpom, M.;  Chewonarin, T.;  Koonyosying, P.;  Cilibrizzi, A.; Srichairatanakool, S., Coprogen B from Talaromyces marneffei DeltasreA: Rapid Iron Chelation and Favorable Partitioning to Deferoxamine. Int J Mol Sci 2025, 26 (23).
  7. Xu, H.; Settakorn, K.;  Khantamat, O.;  Li, J.;  Charoenphandhu, N.;  Chanpaisaeng, K.;  Paradee, N.;  Srichairatanakool, S.; Koonyosying, P., Administration of green tea polyphenols mitigates iron-overload-induced bone loss in a beta-thalassemia mouse model. NPJ Sci Food 2025, 9 (1), 239.
  8. Jiampochaman, T.; Tongsong, T.;  Srichairatanakool, S.;  Koonyosying, P.;  Paradee, N.;  Kerdto, O.; Luewan, S., Assessment of Hepcidin-25 and Iron Status Profiles in Pregnant Women With Thalassemia Minor. J Pregnancy 2025, 2025, 6150362.
  9. Ravikumar, Y.; Razack, S. A.;  Sivashankar, S.;  Srichairatanakool, S.;  Koonyosying, P.; Srichairatanakool, S., Discovery of novel SND1 inhibitors by in silico-based molecular docking and dynamics simulation methods for managing hepatocellular carcinoma. Sci Rep 2025, 15 (1), 30701.
  10. Kerdto, O.; Koonyosying, P.;  Paradee, N.;  Junrungsee, S.;  Chalortham, N.;  Wongsawad, P.;  Yawootti, A.;  Wongmuangsinghanat, A.; Srichairatanakool, S., Genome Characterization of Stelechocarpus burahol (Blume) Hook.f. & Thomson “Kepel” and Exploration of Phytochemicals from Water and Ethanolic Extracts of Leaves and Fruits. Foods 2025, 14 (20).
  11. Likitsatian, T.; Koonyosying, P.;  Roytrakul, S.;  Srisilapanan, P.;  Srichairatanakool, S.; Ruangsuriya, J., Developments and Assessments of Crude Tea Saponin-Incorporated Silica Nanoparticles for Their Bioactivity Improvement. J Funct Biomater 2025, 16 (10).
  12. Chuljerm, H.; Paradee, N.;  Settakorn, K.;  Srichairatanakool, S.;  Yawootti, A.;  Kulprachakarn, K.;  Parklak, W.; Koonyosying, P., Pulsed electric field (PEF)-processed 6-shogaol-rich ginger extract protects beta-Thalassemic red blood cells from iron-induced oxidative stress and hemolysis. PLoS One 2025, 20 (9), e0332386.
  13. Xu, H.; Khantamat, O.;  Korsieporn, W.;  Paradee, N.;  Li, J.;  Zhong, Y.;  Srichairatanakool, S.; Koonyosying, P., Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells. Antioxidants (Basel) 2025, 14 (7).
  14. Paradee, N.; Yimcharoen, T.;  Utama-Ang, N.;  Settakorn, K.;  Chuljerm, H.;  Srichairatanakool, S.; Koonyosying, P., Phytochemical Analysis and Anti-Lipid Accumulation Effects of Pulsed Electric Field (PEF)-Processed Black Rice and Green Tea Extracts in Oleic Acid-Induced Hepatocytes. Food Sci Nutr 2025, 13 (6), e70329.
  15. Prommachote, W.; Deeudom, M.;  Koonyosying, P.;  Srichomphoo, P.;  Somnabut, R.;  Khamnoi, P.;  Cilibrizzi, A.;  Ravikumar, Y.; Srichairatanakool, S., Drug Susceptibility, Siderophore Production, and Genome Analysis of Staphylococcus aureus Clinical Isolates from a University Hospital in Chiang Mai, Thailand. Antibiotics (Basel) 2025, 14 (5).
  16. Likitsatian, T.; Koonyosying, P.;  Paradee, N.;  Roytrakul, S.;  Ge, H.;  Pourzand, C.; Srichairatanakool, S., Camellia Tea Saponin Ameliorates 5-Fluorouracil-Induced Damage of HaCaT Cells by Regulating Ferroptosis and Inflammation. Nutrients 2025, 17 (5).
  17. Jarujareet U., Wiratchawa K., Petiwathayakorn T., Koonyosying P., Hantrakool S., Srichairatanakool S., Intharah T. Classification of beta-thalassemia major and HbE/beta-thalassemia via deep learning of image structure function image (2025) Biomedical Signal Processing and Control, 102, 107265. DOI: 10.1016/j.bspc.2024.107265
  18. Jaikham P., Leelapornpisid P., Tragoolpua K., Koonyosying P., Lin W.-C., Poomanee W. Transethosomes-encapsulated Bouea macrophylla seed extract for anti-acne application: Formulation optimization, antibacterial efficacy, and safety assessment (2025) Journal of Agriculture and Food Research, 20, 101764. DOI: 10.1016/j.jafr.2025.101764
  19. Pokharel, B.; Ravikumar, Y.;  Rathinavel, L.;  Chewonarin, T.;  Pongpom, M.;  Tipsuwan, W.;  Koonyosying, P.; Srichairatanakool, S., The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of beta-Thalassemia through Computational Methods. Molecules 2024, 29 (11).
  20. Petiwathayakorn, T.; Hantrakool, S.;  Settakorn, K.;  Hutachok, N.;  Tantiworawit, A.;  Chalortham, N.;  Koonyosying, P.; Srichairatanakool, S., Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent beta-Thalassemia: A Randomized Placebo-Controlled Clinical Trial. Foods (Basel, Switzerland) 2024, 13 (23).
  21. Chatupos, V.; Neelawatanasook, S.;  Sangutai, T.;  Khanutwong, A.;  Srichairatanakool, P.;  Tipsuwan, W.;  Kerdto, O.;  Paradee, N.;  Koonyosying, P.; Srichairatanakool, S., Comparison of Analgesic and Anti-Inflammatory Effects of Kale Extract Versus Ibuprofen After Impacted Mandibular Third Molar Surgery: A Randomized, Double-Blind Split-Mouth Clinical Trial. Nutrients 2024, 16 (22).
  22. Li, J.; Chuljerm, H.;  Settakorn, K.;  Xu, H.;  Ma, Y.;  Korsieporn, W.;  Paradee, N.;  Srichairatanakool, S.; Koonyosying, P., A novel synthetic compound, deferiprone-resveratrol hybrid (DFP-RVT), promotes hepatoprotective effects and ameliorates iron-induced oxidative stress in iron-overloaded beta-thalassemic mice. Biomed Pharmacotherapy 2024, 180, 117570.
  23. Effects of Drying Methods on the Phytochemical Contents, Antioxidant Properties, and Anti-Diabetic Activity of Nasturtium officinale R.Br. (Betong Watercress) from Southern Thailand. Kijkuokool, P.; Stepanov, I.; Ounjaijean, S.; Koonyosying, P.; Rerkasem, K.; Chuljerm, H.; Parklak, W.; Kulprachakarn, K. (2024) Life, 14 (9)
  24. Pothirat, P.; Wattananapakasem, I.; Leelapornpisid, ; Koonyosying, P.; Yaowiwat, N.; Nawong, S.; Poomanee W. Enhancement of Biological Activities and Phytochemical Compounds of Oryza sativa L. Extract through Probiotic Fermentation. Natural and Life Sciences Communications, 2024, 23(3), e2024029
  25. Hantrakool, S.; Sriwichai, M.;  Shaengkhamnang, B.;  Leetrakool, N.;  Niprapan, P.;  Kawichai, S.;  Wannakul, S.;  Panyasit, N.;  Tuntivate, P.;  Wongtagan, O.;  Natesirinilkul, R.;  Koonyosying, P.;  Phinyo, P.;  Punnachet, T.;  Hantrakun, N.;  Piriyakhuntorn, P.;  Rattanathammethee, T.;  Chai-Adisaksopha, C.;  Rattarittamrong, E.;  Tantiworawit, A.;  Norasetthada, L.; Srichairatanakool, S., The effects of ambient particulate matter air pollution on platelets and hemostasis. Front Public Health 2024, 12, 1410406.
  26. Petiwathayakorn, T.; Paradee, N.;  Hantrakool, S.;  Jarujareet, U.;  Intharah, T.;  Srichairatanakool, S.; Koonyosying, P., A Compact Differential Dynamic Microscopy-based Device (cDDM): An Approach Tool for Early Detection of Hypercoagulable State in Transfusion-Dependent-beta-Thalassemia Patients. ACS Appl Bio Mater 2024.
  27. Pokharel, B.; Ravikumar, Y.;  Rathinavel, L.;  Chewonarin, T.;  Pongpom, M.;  Tipsuwan, W.;  Koonyosying, P.; Srichairatanakool, S., The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of beta-Thalassemia through Computational Methods. Molecules 2024, 29 (11).
  28. Li, J.; Koonyosying, P.; Korsieporn, W.; Paradee, N.; Hutachok, N.; Xu, H.; Ma, Y.; Chuljerm, H.; Srichairatanakool, S., Deferiprone–resveratrol hybrid attenuates iron accumulation, oxidative stress, and antioxidant defenses in iron-loaded human Huh7 hepatic cells. Front. Mol. Biosci 2024, 11:1364261
  29. Wichaiyo, S.; Koonyosying, P.; Morales, N. P., Functional Roles of Furin in Cardio-Cerebrovascular Diseases. ACS Pharmacol Transl Sci 2024, 7 (3), 570-585.
  30. Paradee, N.; Janthip, R.; Taesothikul, T.; Kanjanapothi, D.; Settakorn, K.; Srichairatanakool, S.; Koonyosying, P. Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models. Appl. Sci. 2023, 13, 12216
  31. Settakorn, K.; Hantrakool, S.; Petiwathayakorn, T.; Hutachok, N.; Tantiworawit, A.; Charoenkwan, P.; Chalortham, N.; Chompupoung, A.; Paradee, N.; Koonyosying, P.; Srichairatanakool, S., A randomized placebo-controlled clinical trial of oral green tea epigallocatechin 3-gallate on erythropoiesis and oxidative stress in transfusion-dependent beta-thalassemia patients. Front Mol Biosci 2023, 10, 1248742.
  32. Ravikumar, Y.; Koonyosying, P.; Srichairatanakool, S.; Ponpandian, L. N.; Kumaravelu, J.; Srichairatanakool, S., In Silico Molecular Docking and Dynamics Simulation Analysis of Potential Histone Lysine Methyl Transferase Inhibitors for Managing beta-Thalassemia. Molecules 2023, 28 (21).
  33. Chuljerm, H.; Paradee, N.; Katekaew, D.; Nantachai, P.; Settakorn, K.; Srichairatanakool, S.; Koonyosying, P. Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Plants 2023, 12, 2936. https://doi.org/10.3390/plants12162936
  34. Kampoun, T.; Koonyosying, P.; Ruangsuriya, J.; Prommana, P.; Shaw, P. J.; Kamchonwongpaisan, S.; Suwito, H.; Puspaningsih, N. N. T.; Uthaipibull, C.; Srichairatanakool, S., Antagonistic antimalarial properties of a methoxyamino chalcone derivative and 3-hydroxypyridinones in combination with dihydroartemisinin against Plasmodium falciparum. PeerJ 2023, 11, e15187.
  35. Hutachok, N.; Koonyosying, P.; Paradee, N.; Samakradhamrongthai, R. S.; Utama-Ang, N.; Srichairatanakool, S., Testing the Feasibility and Dietary Impact of Macaroni Fortified with Green Tea and Turmeric Curcumin Extract in Diabetic Rats. Foods 2023, 12 (3).
  36. Settakorn, K.; Kongkarnka, S.; Chompupoung, A.; Svasti, S.; Fucharoen, S.; Porter, J. B.; Srichairatanakool, S.; Koonyosying, P., Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded beta-thalassemic mice. Front Physiol 2022, 13, 1053060.
  37. Chuljerm, H.; Maneekesorn, S.; Punsawad, C.;  Somsak, V.;  Ma, Y.;  Ruangsuriya, J.;  Srichairatanakool, S.; Koonyosying, P., Deferiprone-Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice. Bioinorg Chem Appl 2022, 2022, 3869337.
  38. Koonyosying, P.; Kusirisin, W.; Kusirisin, P.;  Kasempitakpong, B.;  Sermpanich, N.;  Tinpovong, B.;  Salee, N.;  Pattanapanyasat, K.;  Srichairatanakool, S.; Paradee, N., Perilla Fruit Oil-Fortified Soybean Milk Intake Alters Levels of Serum Triglycerides and Antioxidant Status, and Influences Phagocytotic Activity among Healthy Subjects: A Randomized Placebo-Controlled Trial. Nutrients 2022, 14 (9).
  39. Phimphilai, S.; Koonyosying, P.; Hutachok, N.; Kampoun, T.; Daw, R.; Chaiyasut, C.; Prasartthong-Osoth, V.; Srichairatanakool, S., Identifying Chemical Composition, Safety and Bioactivity of Thai Rice Grass Extract Drink in Cells and Animals. Molecules 2021, 26 (22).
  40. Than, M. M.; Koonyosying, P.; Ruangsuriya, J.; Junrungsee, S.; Uthaipibull, C.; Srichairatanakool, S., Effect of Recombinant Human Erythroferrone Protein on Hepcidin Gene (Hamp1) Expression in HepG2 and HuH7 Cells. Materials (Basel) 2021, 14 (21).
  41. Lerttrakarnnon, P.; Kusirisin, W.; Koonyosying, P.; Flemming, B.; Utama-Ang, N.; Fucharoen, S.; Srichairatanakool, S., Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects. Molecules 2021, 26 (20).
  42. Chuljerm, H.; Maneekesorn, S.; Somsak, V.; Ma, Y.; Srichairatanakool, S.; Koonyosying, P., Anti-Malarial and Anti-Lipid Peroxidation Activities of Deferiprone-Resveratrol Hybrid in Plasmodium berghei-Infected Mice. Biology 2021, 10 (9).
  43. Settapramote, N.; Utama-Ang, N.; Petiwathayakorn, T.; Settakorn, K.; Svasti, S.; Srichairatanakool, S.; Koonyosying, P., Antioxidant Effects of Anthocyanin-Rich Riceberry Rice Flour Prepared Using Dielectric Barrier Discharge Plasma Technology on Iron-Induced Oxidative Stress in Mice. Molecules 2021, 26 (16).
  44. Hutachok, N.; Koonyosying, P.; Pankasemsuk, T.; Angkasith, P.; Chumpun, C.; Fucharoen, S.; Srichairatanakool, S. Chemical Analysis, Toxicity Study, and Free-Radical Scavenging and Iron-Binding Assays Involving Coffee (Coffea arabica) Extracts. Molecules 2021, 26, 4169. doi: 10.3390/molecules26144169
  45. Maneekesorn, S.; Chuljerm, H.; Koonyosying, P.; Uthaipibull, C.; Ma, Y.; Srichairatanakool, S. Identifying a Deferiprone–Resveratrol Hybrid as an Effective Lipophilic Anti-Plasmodial Agent. Molecules 2021, 26, 4074. doi: 10.3390/molecules26134074
  46. Paradee N, Koonyosying P, Kusirisin W, Janthip R, Kanjanapothi D, Pattanapanyasat K, et al. Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals. Biosci Rep. 2021;41(1).
  47. Pimpisid Koonyosying, Ben Flemming, Winthana Kusirisin, Peerasak Lerttrakarnnon, Niramon Utama-ang, Suthat Fucharoen6 & Somdet Srichairatanakool. Production, iron analysis and consumer perception of functional Thai Sinlek iron rice (Oryza sativa) drink. International Journal of Food Science and Technology, 2020, EPubDate 10 October 2020
  48. Koonyosying, P., Tantiworawit, A., Hantrakool, S., Utama-Ang, N., Cresswell, M., Fucharoen, S., Porter, J. B., Srichairatanakool, S. Consumption of a green tea extract-curcumin drink decreases blood urea nitrogen and redox iron in beta-thalassemia patients. Food Funct, 2020, EPubDate 2020/01/18
  49. Narisara Paradee, Duangta Kanjanapothi, Tawat Taesotikul, Sarawut Kongkarnka, Adchara Prommaban, Pimpisid Koonyosying, Somdet Srichairatanakool. Thai Perilla frutescens fruit oil alleviates carbon tetrachloride-induced hepatotoxicities in rats. Asian Pac J Trop Biomed, 2020
  50. Pimpisid Koonyosying., Ben Flemming., Supachai Ekwattanakit., Vip Viprakasit., Suthat Fucharoen., Somdet Srichairatanakool. Optimal Use of Thai Sinlek Rice (IR) Provides the Nutraceutical Effect on Erythropoiesis in Rats. Blood (2019) 134 (Supplement_1): 4808, November 2019
  51. Koonyosying, P., Uthaipibull, C., Fucharoen, S., Koumoutsea, E. V., Porter, J. B., Srichairatanakool, S. Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract. Pancreas, 48(5): 636-643 (Part of Ph.D. Thesis work)
  52. Koonyosying, P., Kongkarnka, S., Uthaipibull, C., Svasti, S. Fucharoen, S., Srichairatanakool, S. Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation. Biomed Pharmacother, 2019, 108: 1694-1702 (Part of Ph.D. Thesis work)
  53. Vlachodimitropoulou, E., Chen, Y. L., Garbowski, M., Koonyosying, P., Psaila, B., Sola-Visner, M., Cooper, N., Hider, R., Porter, J. Eltrombopag: a powerful chelator of cellular or extracellular iron (III) alone or combined with a second chelator. Blood, 130(17): 1923-1933 (Part of Ph.D. Thesis work)
  54. Evangelia Vlachodimitropoulou Koumoutsea, Pimpisid Koonyosying, John B. Porter, Nichola Cooper, Bethan Psaila and Martha Sola-Visner (2016). Eltrombopag (ELT) Reverses Iron Mediated Suppression of Insulin Secretion in Pancreatic Cells by Chelating Iron and Decreasing ROS. American Society of Hematology (Blood) 2016 128:1278)

Training Fellowships

  1. “5 th Intellectual property protection training” 22-23 June, 2017 at Agricultural Research Development Agency (Public Organization), Thailand.
  2. Training of advance animal techniques. National Laboratory Animal Center, 14 -15 February 2019, Mahidol University, Thailand. (License number: U1-08220-2562)
  3. Ethical Conduct for Research Involving Humans Workshop, Ethical Review Committees in Thailand, 15 February 2020, Bangkok, Thailand.
  4. 2020 C3BRID Training Course in Infectious Disease for Thai Researchers, organized by Seoul National University Hospital, Clinical Trials Center, 16-17 October 2020 (Certificate No. 2010-15)