Ariyaphong Wongnoppavich, Ph.D. 
รศ.ดร.อริยพงษ์ วงษ์นพวิชญ์

Position Associate Professor

Telephone 053-934437 Ext 216

Email ariyaphong.w@cmu.ac.th

Education

  • 2002        Doctor of Philosophy (Biochemistry), Medical College of Wisconsin, Wisconsin, USA
  • 1995        Bachelor of Science (Biochemistry) (Honor), Chulalongkorn University, Thailand

Professional Experience

  • 2007    Lecturer
  • 2009    Assistant Professor
  • 2020    Associate Professor

Research Interests

  1. Biochemistry and Molecular Biology of Cancer
  2. Natural products as anti-cancer or anti-diabetic agents

Scholarship & Awards

  • 1996    The Royal Thai Government Scholarship (OCSC)

Publications

  • 1999    Twining SS, Wilson PM, Ngamkitidechakul C. Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1alpha and -1beta. Biochem. J. 1999;339: 705-712.
  • 2001    Ngamkitidechakul C, Burke JM, O Brien WJ, Twining SS. Maspin: Synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Invest. Ophthalmol. Vis. Sci. 2001;42:3135-3141
  • 2002    Ngamkitidechakul C, Twining SS. A buffered non-fermenter system for production of secreted recombinant His-tagged proteins in Saccharomyces cerevisiae. Biotechniques, 2002; 33:1296-1300.
  • 2003    Ngamkitidechakul C, Warejka D, Burke JM, O Brien WJ, Twining SS. Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion: conversion of ovalbumin to a maspin-like molecule. J. Biol. Chem. 2003;278(34):31796-806.
  • 2006    Chairatvit K, Ngamkitidechakul C. The ubiquitin-proteasome pathway: regulation of eukaryotic cell cycle and cell cycle abnormalities in (Oral) cancer cells J. Dental. Assoc. Thai. 2006;56(6):433-442
  • 2007    Chairatvit K, Ngamkitidechakul C. Control of Cell Proliferation via Elevated NEDD8 Conjugation in Oral Squamous Cell Carcinoma. Mol Cell Biochem. 2007;303:163-169.
  • 2008    Pinmai K, Chunlaratthanabhorn S, Ngamkitidechakul C, et al. Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents. World J Gastroenterol. 2008;14(10):1491-7.
  • 2009    Hansakul P, Ngamkitidechakul C, et al. Antiproliferative, apoptotic induction, and anti-invasive effects of Leersia hexandra, Panicum repens Linn., and Brachiaria mutica extracts on human cancer cells. Songklanakarin J. Sci. Technol. 2009; 31(1): 79-84.
  • 2009    Wongnoppavich A, Jaijoi K, Sireeratawong S. Triphala: The Thai traditional herbal formulation for cancer treatment Songklanakarin J. Sci. Technol. 2009;31 (2): 139-149.
  • 2009    Hansakul P, Ngamkitidechakul C, et al. Apoptotic induction activity of Dactyloctenium aegyptium and Eleusine indica extracts on human lung and cervical cancer cell lines. Songklanakarin J. Sci. Technol. 2009; 31(3): 273-279.
  • 2010    Charoenteeraboon J, Ngamkitidechakul C, et al. Antioxidant activities of the standardized water extract from fruit of Phyllanthus Emblica Linn. Songklanakarin J. Sci. Technol. 2010; 32(6): 599-604.
  • 2010    Ngamkitidechakul C, Jaijoy K, et al. Antitumor Effects of Phyllanthus Emblica Linn.: Induction of Cancer Cell Apoptosis and Inhibition of In Vivo Tumor Promotion and In Vitro Invasion of Human Cancer Cells. Phytother. Res. 2010; 24(9): 1405-1413
  • 2012    Chairatvit K, Wongnoppavich A, Choonate S. Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-alpha via type I interferon-dependent and -independent pathways. Mol Cell Biochem. 2012; 368 (1-2): 195-201
  • 2013    Taka T, Huang L, Wongnoppavich A, Tam-Chang SW, Lee TR, Tuntiwechapikul W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg Med Chem. 2013;21(4):883-90.
  • 2013    Khanaree C, Chairatvit K, Roytrakul S, Wongnoppavich A. Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level. Oncol Res. 2013;20(9): 427-435.
  • 2014    Khumrin P, Wongnoppavich A, Boonploy K, Supajatura V. A new approach to Computer-Based Examinations using word documents and spreadsheets. Int J Comput Tech. 2014; 12(3): 3319-3324
  • 2015    Kunnaja P, Chiranthanut N, Kunanusorn P, Khonsung P, Wongnoppavich A, Panthong A. Evaluation of gastroprotective potential of the ethanol extract from Murdannia loriformis in rats. Int J Appl Res Nat Prod 2015;8(1):34-41.
  • 2016    Munkong N, Hansakul P, Yoysungnoen B, Wongnoppavich A, Sireeratawong S, Kaendee N, Lerdvuthisopon N, Vasoprotective effects of rice bran water extract on rats fed with high-fat diet, Asian Pac J Trop Biomed 2016; 6(9):778-784.
  • 2017    Budluang P, Pitchakarn P, Ting P, Temviriyanukul P, Wongnoppawich A., and Imsumran A. Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus. Food Sci Nut 2017; 5:486-96.
  • 2017    Wongnoppavich A, Dukaew N, Choonate S, Chairatvit K. Upregulation of maspin expression in human cervical carcinoma cells by transforming growth factor beta1 through the convergence of Smad and non-Smad signaling pathways. Oncol Letters. 2017; 13(5):3646-365.
  • 2017    Na Takuathung M, Wongnoppavich A, Pitchakarn P, et al. Effects of wannachawee recipe with antipsoriatic activity on suppressing inflammatory cytokine production in HaCaT human keratinocytes. Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 5906539, 12 pages, 2017. https://doi.org/10.1155/2017/5906539
  • 2017    Thienthiti K, Tuchinda P, Wongnoppavich A, Soonthornchareonnon N. Cytotoxic effect of compounds isolated from Goniothalamus marcanii Craib stem barks. Pharm Sci Asia, 2017; 44 (2): 86-95. doi:10.29090/PSA.2017.02.086
  • 2017    Phannasorn W, Khanaree C, Wongnoppavich A, Chewonarin T. The effect of purple rice (Oryza sativa L. indica) extract on the inflammatory response in a colon cancer cell line and dextran sulfate-induced tumor promotion in the rat colon. Mol. Cell. Toxicol.2017; 13(4): 433-442. https://doi.org/10.1007/s13273-017-0047-0
  • 2018    Thanuphol P, Asami Y, Shiomi K, Wongnoppavich A, Tuchinda P, Soonthornchareonnon N. Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib. Natural Product Research. 2018, Natural Product Research, 2018; (14):1682-1689. https://doi.org/10.1080/14786419.2017.1396588
  • 2018    Na Takuathung M, Wongnoppavich A, Panthong A, et al. Antipsoriatic effects of wannachawee recipe on imiquimod-induced psoriasis-like dermatitis in BALB/c mice. Evid Based Complement Alternat Med. 2018 Jan 24;2018:7931031. https://doi.org/10.1155/2018/7931031
  • 2019    Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavich A, Konishi T. Emerging role of secondary bystander effects induced by fractionated proton microbeam radiation. Radiation Research, 2019;191(2):211-216. https://doi.org/10.1667/RR15155.1
  • 2019    Pouyfung P, Choonate S, Wongnoppavich A, Rongnoparut P, Chairatvit K. Anti-proliferative effect of 8 alpha-tigloyloxyhirsutinolide-13-O-acetate (8alphaTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation. Phytomedicine, 2019; 52: 238-246. https://doi.org/10.1016/j.phymed.2018.09.211 Epub 2018 Sep 26.
  • 2019    Kaewtunjai N, Summart R, Wongnoppavich A, Lojanapiwat B, Lee TR, Tuntiwechapikul W. Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells. Biol Pharm Bull. 2019 Jun 1;42(6):906-914. https://doi.org/10.1248/bpb.b18-00860 Epub 2019 Mar 30.
  • 2019   Autsavapromporn N, Dukaew N, Wongnoppavich A, Chewaskulyong B, Roytrakul S, Klunklin P, Phantawong K, Chitapanarux I, Sripun P, Kritsananuwat R, Amphol S, Pornnumpa C, Suzuki T, Kudo H, Hosoda M, Tokonami S. Identification of novel biomarkers for lung cancer risk in high levels of radon by proteomics: a pilot study. Radiat Prot Dosimetry. 2019 Oct 1;184(3-4):496-499. https://doi.org/10.1093/rpd/ncz064. PubMed PMID: 31330007.
  • 2019   Lertsooksawat W, Wongnoppavich A, Chairatvit K. Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma. Mol Cell Biochem, 2019;462(1-2):51-59. https://doi.org/10.1007/s11010-019-03609-5
  • 2020   Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A. Enhancement of radiosensitivity by eurycomalactone in human NSCLC cells through G2/M cell cycle arrest and delayed DNA double-strand break repair. Oncol Res. 2020;28:161-175. https://doi.org/10.3727/096504019X15736439848765
  • 2020   Dukaew N, Chairatvit K, Pitchakarn P, Imsumran A, Karinchai J, Tuntiwechapikul W and Wongnoppavich A. Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020; 44: 1441-1454. https://doi.org/10.3892/or.2020.7710
  • 2021   Karinchai J, Budluang P, Temviriyanukul P, Ting P, Nuchuchua O, Wongnoppavich A, Imsumran A, Pitchakarn P. Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7 cells. J Ethnopharmacol. 2021 Jul 24;280:114452. https://doi.org/10.1016/j.jep.2021.114452
  • 2023   Buacheen P, Karinchai J, Kammasit N, Temviriyanukul P, Butkinaree C, Watthana S, Wongnoppavich A, Imsumran A, Pitchakarn P. Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A. Sci Rep. 2023 Feb 20;13(1):2939. 10.1038/s41598-023-30227-5
  • 2023   Buacheen P, Chaipuang A, Karinchai J, Nuchuchua O, Imsumran A, Wongnoppavich A, Pimpha N, Pitchakarn P. Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using Anoectochilus burmannicus Extract as a Potential Novel Functional Ingredient. Nutrients. 2023 Feb 17;15(4):1018 https://doi.org/10.3390/nu15041018
  • 2023   Nuchuchua O, Inpan R, Srinuanchai W, Karinchai J, Pitchakarn P, Wongnoppavich A, Imsumran A. Phytosome Supplements for Delivering Gymnema inodorum Phytonutrients to Prevent Inflammation in Macrophages and Insulin Resistance in Adipocytes. Foods. 2023 June 3;12(11):2257. https://doi.org/10.3390/foods12112257
  • 2023   Na Takuathung M, Wongnoppavich A, Jaijoy K, Soonthornchareonnon N, Sireeratawong S. Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula. Natural Product Communications. 2023;18(6). 10.1177/1934578X231176925
  • 2023   Vachiraarunwong A, Tuntiwechapikul W, Wongnoppavich A, Meepowpan P, Wongpoomchai R. 2,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone from Cleistocalyx nervosum var. paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis. 2023 Sep; 165: 115221 https://doi.org/10.1016/j.biopha.2023.115221
  • 2023   Klaophimai S, Pouyfung P, Wongnoppavich A, Chairatvit K. Induction of S arrest and apoptosis in human oral cancer cells by Rhinacanthin-C extracted from Rhinacanthus nasutus via modulating Akt and p38 signaling pathways. J. Ethnopharmacol. 2023 Dec 5; 317: 116813. https://doi.org/10.1016/j.jep.2023.11681

 

Proceedings

  • 2014.    Waloh N, Wongnoppavich A, Bonness A. Effects of Purple Rice (Oryza sativa L.) on Adipogenesis and Inflammation-induced Insulin Resistance in Adipocyte. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
  • 2014.    Waloh N, Bonness A., Wongnoppavich A. Inhibitory Effects of Azadirachta indica Leaf Ethanolic Extract on Inflammation in Macrophage and Insulin Resistance in Adipocyte. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
  • 2014.    Kaewprasert P, Waloh N, Wongnoppavich A, Bonness A. In vitro Anti-inflammatory and Anti-insulin Resistant Activities of Solanum torvum and Solanum trilobatum Fruit Ethanolic Extracts. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
  • 2018.    Rodthayoy N, Karinchai J, Dukaew N, Buacheen P, Wongnoppavich A, (Imsumran) Bonness A, Khantamat O, Chantarasuwan B, Temviriyanukul P, Pitchakarn P. Effect of Ficus dubia latex and root extracts in lipopolysaccharide-induced macrophages. Oral presentation/ Proceedings at the 1st Innovation of Functional Foods in Asia (IFFA 2018) Jan 22-24, 2018, Phayao, Thailand

Oral Presentation

  • 2019. Eurycomalactone Synergistically Enhances Cisplatin Sensitivity in Non-small Cell Lung Cancer via Suppressing NF-kB p65, The 78th Annual Meeting of the Japanese Cancer Association., September 28, 2019, Kyoto, Japan

Poster Presentation

  • 2014.    Up-regulation of the Maspin Gene Expression by Transforming Growth Factor-beta (TGF-beta) in Human Cervical Carcinoma Cells, The 73rd Annual Meeting of the Japanese Cancer Association, September 25-27, 2014, Yokohama, Japan

Books

  1. ตำราชีวเคมีพื้นฐานสำหรับวิทยาศาตร์การแพทย์ เล่ม 1 คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่ 2558 พงษ์สวัสดิ์การพิมพ์ เชียงใหม่
  2. ตำราอณูชีววิทยา เล่ม 2 : ยีน อาร์เอ็นเอ และโปรตีน 2563 โรงพิมพ์คณะแพทยศาสตร์ มหาวิยาลัยเชียงใหม่ เชียงใหม่

Editorial Services

  1. BMC Complementary and Alternative Medicine
  2. BMC Biotechnology
  3. Experimental and Therapeutic Medicine
  4. International Journal of Oncology
  5. International Journal of Molecular Medicine
  6. IUBMB Life
  7. Journal of Herbal Medicine
  8. Journal of Cancer Science and Therapy
  9. Maejo International Journal of Science and Technology
  10. Molecular Medicine Reports
  11. Oncology Letters
  12. Oncology Reports
  13. Oncology Research
  14. OncoTargets and Therapy
  15. Phytotherapy Research
  16. Srinagarin  Medical Journal
  17. The Science Society of Thailand
  18. Walailak Journal of Science and Technology

Society Memberships

  1. Biochemistry and Molecular Biology Section, The Science Society of Thailand Under the Patronage of His Majesty the King

Research Grants

  • 2010    Effect of Pro-inflammatory Cytokines on Expression of Maspin in Human Cancer Cell Lines    National Research Council of Thailand    Principle Investigator    660,000 Baht
  • 2012    Characterization of Biological Activities in Purple Rice on Inhibition of Adipogenesis and Insulin Resistance in Fat Cells    Agricultural Research Development Agency    Principle Investigator    785,500 Baht
  • 2012    Molecular Mechanism of Maspins RCL on Anti-invasion of Human Breast Carcinoma Cells    Faculty of Medicine, Chiang Mai University    Principle Investigator    200,000 Baht
  • 2013    Anti-adipogenesis and Anti-insulin Resistant Activities of Five Thai Herbal Vegetables    National Research Council of Thailand    Principle Investigator    775,000 Baht
  • 2013    Effects of Ethanolic Extract from Azardirachta Indica and Gymnema Inodorum Leaves on Anti-inflammation in Macrophage and Anti-insulin Resistance in Adipocyte    Faculty of Medicine, Chiang Mai University    Principle Investigator    200,000 Baht
  • 2015    Transcriptional Regulation of Maspin Expression by Transforming Growth Factor-beta in Human Cervical Carcinoma Cell    Faculty of Medicine, Chiang Mai University    Principle Investigator    200,000
  • 2015    Protective effects of purple rice grass extract on mutagenesis and insulin resistance in adipocyte    Agricultural Research Development Agency (Public Organization)    Principle Investigator    600,000
  • 2017    Radiosensitization of Purified Compounds from Thai Herbs against Human Non-Small Cell Lung Cancer Cells    Faculty of Medicine, Chiang Mai University    Principle Investigator    200,000 Baht
  • 2017    Chemosynergism Effect of Purified Compounds from Thai Herbs against Human Non-Small Cell Lung Cancer Cells    Faculty of Medicine, Chiang Mai University,   Principle Investigator    200,000 Baht

Graduate Students (as a major advisor)

  • 2014   Nahathai Dukaew   570751035 (นักศึกษาปริญญาเอก ทุน คปก. รุ่นที่ 18)
  • 2022  Kongsakon Kulchim  650755905