Ariyaphong Wongnoppavich, Ph.D.
รศ. ดร.อริยพงษ์ วงษ์นพวิชญ์

Position Associate Professor
Telephone 053-934437 Ext 216
Email ariyaphong.w@cmu.ac.th
Education
- 2002 Doctor of Philosophy (Biochemistry), Medical College of Wisconsin, Wisconsin, USA
- 1995 Bachelor of Science (Biochemistry) (Honors), Chulalongkorn University, Thailand
Professional Experience
- 2020 – Present Associate Professor
- 2009 – 2020 Assistant Professor
- 2003 – 2009 Lecturer
Research Interests
- Biochemistry and Molecular Biology of Cancer
- Natural products as anti-cancer, anti-inflammatory, or anti-diabetic agents
Scholarship & Awards
- 1996 – 2000 The Royal Thai Government Scholarship (OCSC)
Publications
- 2026 Kulchim K, Braspaiboon S, Pitchakarn P, Imsumran A, Buacheen P, Laowanitwattana T, Temviriyanukul P, Chairatvit K, Wongnoppavich A. Box–Behnken Design Optimization of High-Pressure Processed Bitter Melon (Momordica charantia) Leaf Extract Enhancing Phytochemicals, Anticancer, and Anti-Inflammatory Activities. International Journal of Molecular Sciences. 2026; 27(11):4945. https://doi.org/10.3390/ijms27114945
- 2025 Soddaen P, Chairatvit K, Pitchakarn P, Laowanitwattana T, Imsumran A, Wongnoppavich A. Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling. International Journal of Molecular Sciences. 2025; 26(15):7120. https://doi.org/10.3390/ijms26157120
- 2025 Deethai P, Siriwathanakul C, Pitchakarn P, Imsumran A, Wongnoppavich A, Dissook S, Chewonarin T. Perilla frutescens Seed Residue Extract Restores Gut Microbial Balance and Enhances Insulin Function in High-Fat Diet and Streptozotocin-Induced Diabetic Rats. International Journal of Molecular Sciences. 2025; 26(17):8176. https://doi.org/10.3390/ijms26178176
- 2025 Temviriyanukul P, Inthachat W, Jaiaree A, Karinchai J, Buacheen P, Yodkeeree S, Laowanitwattana T, Chewonarin T, Suttisansanee U, Imsumran A, Wongnoppavich A, Pitchakarn P. Enhancement of Phytochemicals and Antioxidant Activity of Thai Fermented Soybean Using Box–Behnken Design Guided Microwave-Assisted Extraction. Foods. 2025; 14(15):2603. https://doi.org/10.3390/foods14152603
- 2025 Buacheen P, Karinchai J, Inthachat W, Butkinaree C, Wongnoppavich A, Imsumran A, Temviriyanukul P, Inoue YH, Pitchakarn P. Anoectochilus burmannicus Extract Rescues Aging-Related Phenotypes in Drosophila Susceptible to Oxidative Stress-Induced Senescence. International Journal of Molecular Sciences. 2025; 26(12):5694. https://doi.org/10.3390/ijms26125694
- 2025 Intatham S, Taychaworaditsakul W, Kunnaja P, Wongnoppavich A, Jaijoy K, Chansakaow S, Rojsanga P, Sireeratawong S. Anti-Hangover and Hepatoprotective Effects of the Leaf Extract of Thunbergia laurifolia in Sprague–Dawley Rats. Pharmaceuticals. 2025; 18(5):685. https://doi.org/10.3390/ph18050685
- 2025 Pitchakarn P, Karinchai J, Buacheen P, Imsumran A, Wongnoppavich A, Boonyapranai K, Ounjaijean S. Ficus lindsayana Leaf Extract Protects C2C12 Mouse Myoblasts Against the Suppressive Effects of Bisphenol-A on Myogenic Differentiation. International Journal of Molecular Sciences. 2025; 26(2):476. https://doi.org/3390/ijms26020476
- 2024 Singai C, Pitchakarn P, Taya S, Wongpoomchai R, Wongnoppavich A. Genotoxic and Anti-Genotoxic Assessments of Fermented Houttuynia cordata Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Colon and Liver in Rats. Foods. 2024; 13(22):3645. https://doi.org/10.3390/foods13223645
- 2024 Singai C, Pitchakarn P, Taya S, Phannasorn W, Wongpoomchai R, Wongnoppavich A. Chemopreventive Potential of Phyllanthus emblica Fruit Extract against Colon and Liver Cancer Using a Dual-Organ Rat Carcinogenesis Model. Pharmaceuticals. 2024; 17(7):818. https://doi.org/10.3390/ph17070818
- 2024 Karinchai J, Buacheen P, Rodthayoy D, Yodweerapong T, Imsumran A, Wongnoppavich A, Chantarasuwan B, Suttisansanee U, Temviriyanukul P, Pitchakarn P. Anti-Inflammatory and Anti-Adipocyte Dysfunction Effects of Ficus lindsayana Latex and Root Extracts. Pharmaceuticals. 2024; 17(3):287. https://doi.org/10.3390/ph17030287
- 2023 Klaophimai S, Pouyfung P, Wongnoppavich A, Chairatvit K. Induction of S arrest and apoptosis in human oral cancer cells by Rhinacanthin-C extracted from Rhinacanthus nasutus via modulating Akt and p38 signaling pathways. Journal of Ethnopharmacology. 2023 Dec 5; 317: 116813. https://doi.org/10.1016/j.jep.2023.11681
- 2023 Vachiraarunwong A, Tuntiwechapikul W, Wongnoppavich A, Meepowpan P, Wongpoomchai R. 2,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone from Cleistocalyx nervosum var. paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis. Biomedicine & Pharmacotherapy 2023 Sep; 165: 115221 https://doi.org/10.1016/j.biopha.2023.115221
- 2023 Na Takuathung M, Wongnoppavich A, Jaijoy K, Soonthornchareonnon N, Sireeratawong S. Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula. Natural Product Communications. 2023;18(6). 10.1177/1934578X231176925
- 2023 Nuchuchua O, Inpan R, Srinuanchai W, Karinchai J, Pitchakarn P, Wongnoppavich A, Imsumran A. Phytosome Supplements for Delivering Gymnema inodorum Phytonutrients to Prevent Inflammation in Macrophages and Insulin Resistance in Adipocytes. Foods. 2023 June 3;12(11):2257. https://doi.org/10.3390/foods12112257
- 2023 Buacheen P, Karinchai J, Inthachat W, Butkinaree C, Jankam C, Wongnoppavich A, Imsumran A, Chewonarin T, Pimpha N, Temviriyanukul P, et al. The Toxicological Assessment of Anoectochilus burmannicus Ethanolic-Extract-Synthesized Selenium Nanoparticles Using Cell Culture, Bacteria, and Drosophila melanogaster as Suitable Models. Nanomaterials. 2023; 13(20):2804. https://doi.org/10.3390/nano13202804
- 2023 Buacheen P, Karinchai J, Kammasit N, Temviriyanukul P, Butkinaree C, Watthana S, Wongnoppavich A, Imsumran A, Pitchakarn P. Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A. Scientific Reports. 2023 Feb 20;13(1):2939. 10.1038/s41598-023-30227-5
- 2023 Buacheen P, Chaipuang A, Karinchai J, Nuchuchua O, Imsumran A, Wongnoppavich A, Pimpha N, Pitchakarn P. Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using Anoectochilus burmannicus Extract as a Potential Novel Functional Ingredient. Nutrients. 2023 Feb 17;15(4):1018 https://doi.org/10.3390/nu15041018
- 2021 Karinchai J, Budluang P, Temviriyanukul P, Ting P, Nuchuchua O, Wongnoppavich A, Imsumran A, Pitchakarn P. Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7 cells. Journal of Ethnopharmacology. 2021 Jul 24;280:114452. https://doi.org/10.1016/j.jep.2021.114452
- 2020 Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A. Enhancement of radiosensitivity by eurycomalactone in human NSCLC cells through G2/M cell cycle arrest and delayed DNA double-strand break repair. Oncology Research. 2020;28:161-175. https://doi.org/10.3727/096504019X15736439848765
- 2020 Dukaew N, Chairatvit K, Pitchakarn P, Imsumran A, Karinchai J, Tuntiwechapikul W, and Wongnoppavich A. Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncology Reports. 2020; 44: 1441-1454. https://doi.org/10.3892/or.2020.7710
- 2019 Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavich A, Konishi T. Emerging role of secondary bystander effects induced by fractionated proton microbeam radiation. Radiation Research. 2019;191(2):211-216. https://doi.org/10.1667/RR15155.1
- 2019 Pouyfung P, Choonate S, Wongnoppavich A, Rongnoparut P, Chairatvit K. Anti-proliferative effect of 8 alpha-tigloyloxyhirsutinolide-13-O-acetate (8alphaTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation. Phytomedicine. 2019; 52: 238-246. https://doi.org/10.1016/j.phymed.2018.09.211 Epub 2018 Sep 26.
- 2019 Lertsooksawat W, Wongnoppavich A, Chairatvit K. Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma. Mol Cell Biochem, 2019;462(1-2):51-59. https://doi.org/10.1007/s11010-019-03609-5
- 2019 Autsavapromporn N, Dukaew N, Wongnoppavich A, Chewaskulyong B, Roytrakul S, Klunklin P, Phantawong K, Chitapanarux I, Sripun P, Kritsananuwat R, Amphol S, Pornnumpa C, Suzuki T, Kudo H, Hosoda M, Tokonami S. Identification of novel biomarkers for lung cancer risk in high levels of radon by proteomics: a pilot study. Radiation Protection Dosimetry. 2019 Oct 1;184(3-4):496-499. https://doi.org/10.1093/rpd/ncz064. PubMed PMID: 31330007.
- 2019 Kaewtunjai N, Summart R, Wongnoppavich A, Lojanapiwat B, Lee TR, Tuntiwechapikul W. Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells. Biological and Pharmaceutical Bulletin. 2019 Jun 1;42(6):906-914. https://doi.org/10.1248/bpb.b18-00860 Epub 2019 Mar 30.
- 2018 Thanuphol P, Asami Y, Shiomi K, Wongnoppavich A, Tuchinda P, Soonthornchareonnon N. Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib. Natural Product Research. 2018; (14):1682-1689. https://doi.org/10.1080/14786419.2017.1396588
- 2018 Na Takuathung M, Wongnoppavich A, Panthong A, et al. Antipsoriatic effects of Wannachawee recipe on imiquimod-induced psoriasis-like dermatitis in BALB/c mice. Evidence-Based Complementary and Alternative Medicine. 2018;7931031. https://doi.org/10.1155/2018/7931031
- 2017 Budluang P, Pitchakarn P, Ting P, Temviriyanukul P, Wongnoppawich A, Imsumran A. Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus. Food Science & Nutrition. 2017; 5:486-96. https://doi.org/10.1002/fsn3.416
- 2017 Wongnoppavich A, Dukaew N, Choonate S, Chairatvit K. Upregulation of maspin expression in human cervical carcinoma cells by transforming growth factor beta1 through the convergence of Smad and non-Smad signaling pathways. Oncology Letters. 2017; 13(5):3646-3652. https://doi.org/10.3892/ol.2017.5939
- 2017 Na Takuathung M, Wongnoppavich A, Pitchakarn P, et al. Effects of Wannachawee recipe with antipsoriatic activity on suppressing inflammatory cytokine production in HaCaT human keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2017; 5906539, 12 pages. https://doi.org/10.1155/2017/5906539
- 2017 Thienthiti K, Tuchinda P, Wongnoppavich A, Soonthornchareonnon N. Cytotoxic effect of compounds isolated from Goniothalamus marcanii Craib stem barks. Pharmaceutical Sciences Asia. 2017; 44 (2): 86-95. doi:10.29090/PSA.2017.02.086
- 2017 Phannasorn W, Khanaree C, Wongnoppavich A, Chewonarin T. The effect of purple rice (Oryza sativa L. indica) extract on the inflammatory response in a colon cancer cell line and dextran sulfate-induced tumor promotion in the rat colon. Molecular Cellular Toxicology. 2017; 13(4): 433-442. https://doi.org/10.1007/s13273-017-0047-0
- 2016 Munkong N, Hansakul P, Yoysungnoen B, Wongnoppavich A, Sireeratawong S, Kaendee N, Lerdvuthisopon N, Vasoprotective effects of rice bran water extract on rats fed with high-fat diet, Asian Pacific Journal of Tropical Biomedicine. 2016; 6(9):778-784. https://doi.org/10.1016/j.apjtb.2016.07.009
- 2015 Kunnaja P, Chiranthanut N, Kunanusorn P, Khonsung P, Wongnoppavich A, Panthong A. Evaluation of gastroprotective potential of the ethanol extract from Murdannia loriformis in rats. Int J Appl Res Nat Prod 2015;8(1):34-41.
- 2014 Khumrin P, Wongnoppavich A, Boonploy K, Supajatura V. A new approach to Computer-Based Examinations using word documents and spreadsheets. International Journal of Computers & Technology. 2014; 12(3): 3319-3324. https://share.google/YUGe3oBrOZlqec32g
- 2013 Taka T, Huang L, Wongnoppavich A, Tam-Chang SW, Lee TR, Tuntiwechapikul W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorganic & Medicinal Chemistry. 2013;21(4):883-90. https://doi.org/10.1016/j.bmc.2012.12.020
- 2013 Khanaree C, Chairatvit K, Roytrakul S, Wongnoppavich A. Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level. Oncology Research. 2013;20(9): 427-435. https://doi.org/10.3727/096504013X13657689383175
- 2012 Chairatvit K, Wongnoppavich A, Choonate S. Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-alpha via type I interferon-dependent and -independent pathways. Molecular and Cellular Biochemistry. 2012; 368 (1-2): 195-201. https://doi.org/10.1007/s11010-012-1360-5
- 2010 Ngamkitidechakul C, Jaijoy K, et al. Antitumor Effects of Phyllanthus Emblica Linn.: Induction of Cancer Cell Apoptosis and Inhibition of In Vivo Tumor Promotion and In Vitro Invasion of Human Cancer Cells. Phytotherapy Research. 2010; 24(9): 1405-1413. https://doi.org/10.1002/ptr.3127
- 2010 Charoenteeraboon J, Ngamkitidechakul C, et al. Antioxidant activities of the standardized water extract from fruit of Phyllanthus Emblica Linn. Songklanakarin Journal of Science and Technology. 2010; 32(6): 599-604. https://sjst.psu.ac.th/article/1100/PaperPDFw-Links/download
- 2009 Wongnoppavich A, Jaijoi K, Sireeratawong S. Triphala: The Thai traditional herbal formulation for cancer treatment. Songklanakarin Journal of Science and Technology. 2009;31 (2): 139-149. https://sjst.psu.ac.th/article/949/PaperPDFw-Links/download
- 2009 Hansakul P, Ngamkitidechakul C, et al. Antiproliferative, apoptotic induction, and anti-invasive effects of Leersia hexandra, Panicum repens Linn., and Brachiaria mutica extracts on human cancer cells. Songklanakarin Journal of Science and Technology. 2009; 31(1): 79-84. https://sjst.psu.ac.th/article/941/PaperPDFw-Links/download
- 2009 Hansakul P, Ngamkitidechakul C, et al. Apoptotic induction activity of Dactyloctenium aegyptium and Eleusine indica extracts on human lung and cervical cancer cell lines. Songklanakarin Journal of Science and Technology. 2009; 31(3): 273-279. https://sjst.psu.ac.th/article/965/PaperPDFw-Links/download
- 2008 Pinmai K, Chunlaratthanabhorn S, Ngamkitidechakul C, et al. Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents. World Journal of Gastroenterology. 2008;14(10):1491-7. https://doi.org/10.3748/wjg.14.1491
- 2007 Chairatvit K, Ngamkitidechakul C. Control of Cell Proliferation via Elevated NEDD8 Conjugation in Oral Squamous Cell Carcinoma. Molecular and Cellular Biochemistry. 2007;303:163-169. https://doi.org/10.1007/s11010-007-9566-7
- 2006 Chairatvit K, Ngamkitidechakul C. The ubiquitin-proteasome pathway: regulation of eukaryotic cell cycle and cell cycle abnormalities in (Oral) cancer cells. Journal of the Dental Association of Thailand. 2006;56(6):433-442
- 2003 Ngamkitidechakul C, Warejka D, Burke JM, O Brien WJ, Twining SS. Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion: conversion of ovalbumin to a maspin-like molecule. Journal of Biological Chemistry. 2003;278(34):31796-806. https://doi.org/10.1074/jbc.m302408200
- 2002 Ngamkitidechakul C, Twining SS. A buffered non-fermenter system for production of secreted recombinant His-tagged proteins in Saccharomyces cerevisiae. Biotechniques. 2002; 33:1296-1300. https://doi.org/10.2144/02336pt02
- 2001 Ngamkitidechakul C, Burke JM, O Brien WJ, Twining SS. Maspin: Synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Investigative Ophthalmology & Visual Science. 2001;42:3135-3141. https://iovs.arvojournals.org/article.aspx?articleid=2123343
- 1999 Twining SS, Wilson PM, Ngamkitidechakul C. Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1alpha and -1beta. Biochemical Journal. 1999;339: 705-712. https://pmc.ncbi.nlm.nih.gov/articles/PMC1220207/
Proceedings
- 2018. Rodthayoy N, Karinchai J, Dukaew N, Buacheen P, Wongnoppavich A, (Imsumran) Bonness A, Khantamat O, Chantarasuwan B, Temviriyanukul P, Pitchakarn P. Effect of Ficus dubia latex and root extracts in lipopolysaccharide-induced macrophages. Oral presentation/ Proceedings at the 1st Innovation of Functional Foods in Asia (IFFA 2018) Jan 22-24, 2018, Phayao, Thailand
- 2014. Waloh N, Wongnoppavich A, Bonness A. Effects of Purple Rice (Oryza sativa L.) on Adipogenesis and Inflammation-induced Insulin Resistance in Adipocyte. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
- 2014. Waloh N, Bonness A., Wongnoppavich A. Inhibitory Effects of Azadirachta indica Leaf Ethanolic Extract on Inflammation in Macrophage and Insulin Resistance in Adipocyte. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
- 2014. Kaewprasert P, Waloh N, Wongnoppavich A, Bonness A. In vitro Anti-inflammatory and Anti-insulin Resistant Activities of Solanum torvum and Solanum trilobatum Fruit Ethanolic Extracts. Poster presentation/ Proceedings at The 4th International Biochemistry and Molecular Biology Conference April 2-3, 2014, Bangkok, Thailand
Oral Presentation
- 2019. Eurycomalactone Synergistically Enhances Cisplatin Sensitivity in Non-small Cell Lung Cancer via Suppressing NF-kB p65, The 78th Annual Meeting of the Japanese Cancer Association., September 28, 2019, Kyoto, Japan
Poster Presentation
- 2014. Up-regulation of the Maspin Gene Expression by Transforming Growth Factor-beta (TGF-beta) in Human Cervical Carcinoma Cells, The 73rd Annual Meeting of the Japanese Cancer Association, September 25-27, 2014, Yokohama, Japan
Books
- ตำราชีวเคมีพื้นฐานสำหรับวิทยาศาตร์การแพทย์ เล่ม 1 คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่ 2558 พงษ์สวัสดิ์การพิมพ์ เชียงใหม่
- ตำราอณูชีววิทยา เล่ม 2 : ยีน อาร์เอ็นเอ และโปรตีน 2563 โรงพิมพ์คณะแพทยศาสตร์ มหาวิยาลัยเชียงใหม่ เชียงใหม่
Society Memberships
- Biochemistry and Molecular Biology Section, The Science Society of Thailand Under the Patronage of His Majesty the King
Research Grants
- 2017 Radiosensitization of Purified Compounds from Thai Herbs against Human Non-Small Cell Lung Cancer Cells Faculty of Medicine, Chiang Mai University Principle Investigator 200,000 Baht
- 2017 Chemosynergism Effect of Purified Compounds from Thai Herbs against Human Non-Small Cell Lung Cancer Cells Faculty of Medicine, Chiang Mai University, Principle Investigator 200,000 Baht
- 2015 Transcriptional Regulation of Maspin Expression by Transforming Growth Factor-beta in Human Cervical Carcinoma Cell Faculty of Medicine, Chiang Mai University Principle Investigator 200,000
- 2015 Protective effects of purple rice grass extract on mutagenesis and insulin resistance in adipocyte Agricultural Research Development Agency (Public Organization) Principle Investigator 600,000
- 2013 Anti-adipogenesis and Anti-insulin Resistant Activities of Five Thai Herbal Vegetables National Research Council of Thailand Principle Investigator 775,000 Baht
- 2013 Effects of Ethanolic Extract from Azardirachta Indica and Gymnema Inodorum Leaves on Anti-inflammation in Macrophage and Anti-insulin Resistance in Adipocyte Faculty of Medicine, Chiang Mai University Principle Investigator 200,000 Baht
- 2012 Characterization of Biological Activities in Purple Rice on Inhibition of Adipogenesis and Insulin Resistance in Fat Cells Agricultural Research Development Agency Principle Investigator 785,500 Baht
- 2012 Molecular Mechanism of Maspins RCL on Anti-invasion of Human Breast Carcinoma Cells Faculty of Medicine, Chiang Mai University Principle Investigator 200,000 Baht
Graduate Students (as a major advisor)
- 2022 Kongsakon Kulchim 650755905 (นักศึกษาปริญญาเอก RGJ-PhD ทุน คปก. รุ่นที่ 25)
- 2014 Nahathai Dukaew 570751035 (นักศึกษาปริญญาเอก RGJ-PhD ทุน คปก. รุ่นที่ 18)