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Huy BV, Teeraananchai S, Oanh LN, Tucker J, Kurniati N, Hansudewechakul R, Truong KH, Khol V, Nguyen LV, Chau Do V, Lumbiganon P, Kongstan N, Bunupuradah T, Sudjaritruk T, Kumarasamy N, Yusoff NK, Mohd Razali KA, Wati DK, Fong MS, Nallusamy R, Kariminia A, Sohn AH.
J Virus Erad. 2016 Oct 5;2(4):227-231.
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Abstract
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4-95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11-2.24) were more likely to be lost to follow-up. Although post-ART mortality and retentiondid not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth. |
