{"id":155,"date":"2018-06-26T15:31:39","date_gmt":"2018-06-26T15:31:39","guid":{"rendered":"https:\/\/w1.med.cmu.ac.th\/biochem\/?page_id=155"},"modified":"2026-01-22T07:31:23","modified_gmt":"2026-01-22T07:31:23","slug":"wirote-tuntiwechapikul","status":"publish","type":"page","link":"https:\/\/w1.med.cmu.ac.th\/biochem\/wirote-tuntiwechapikul\/","title":{"rendered":"Wirote Tuntiwechapikul"},"content":{"rendered":"

\"\"Wirote Tuntiwechapikul<\/span><\/strong>
\n\u0e23\u0e28. \u0e14\u0e23.\u0e27\u0e34\u0e42\u0e23\u0e08\u0e19\u0e4c \u0e15\u0e31\u0e19\u0e15\u0e34\u0e40\u0e27\u0e0a\u0e2d\u0e20\u0e34\u0e01\u0e38\u0e25<\/span><\/p>\n

Position<\/strong>\u00a0<\/span>Associate Professor<\/p>\n

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Education<\/h3>\n
    \n
  • 2001<\/strong>\u00a0 \u00a0 \u00a0 \u00a0 Doctor of Philosophy (Medicinal Chemistry), University of Texas at Austin, USA<\/li>\n
  • 1994<\/strong>\u00a0 \u00a0 \u00a0 \u00a0 Master of Science (Biochemistry), Faculty of Medicine, Chiang Mai University, Thailand<\/li>\n
  • 1988<\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bachelor of Pharmacy, Chulalongkorn University, Thailand<\/li>\n<\/ul>\n

     <\/p>\n

    Professional Experience<\/h3>\n
      \n
    • 2002<\/strong>\u00a0\u00a0\u00a0\u00a0Lecturer<\/li>\n
    • 2004<\/strong>\u00a0\u00a0\u00a0\u00a0Assistant Professor<\/li>\n
    • 2014<\/strong>\u00a0\u00a0\u00a0\u00a0Associate Professor<\/li>\n<\/ul>\n

       <\/p>\n

      Research Interests<\/h3>\n
        \n
      1. Anticancer drugs based on telomerase inhibition<\/li>\n<\/ol>\n

         <\/p>\n

        Publications<\/h3>\n
          \n
        • 2001<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, Lee JT, Salazar M. Design and synthesis of the G-quadruplex-specific cleaving reagent Perylene-EDTA-Iron(II). J Am Chem Soc. 2001; 123: 5606-7.<\/li>\n
        • 2001<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, Salazar M. Cleavage of telomeric G-quadruplex DNA with Perylene-EDTA-Fe(II). Biochemistry 2001; 40: 13652-8.<\/li>\n
        • 2002<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, Salazar M. Mechanism of in-vitro expansion of long DNA repeats: effect of temperature, repeat length, and DNA polymerases. Biochemistry 2002; 41: 854-60.<\/li>\n
        • 2002<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, David WM, Kumar D, Kerwin SM, Salazar M. DNA modification by 4-Aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity. Biochemistry 2002; 41: 5283-90.<\/li>\n
        • 2002<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W. Telomerase as a target for anticancer agents. Chiang Mai Med Bull. 2002; 41: 223-31.<\/li>\n
        • 2004<\/strong>\u00a0\u00a0\u00a0\u00a0Pham T, Lai D, Ji D, Tuntiwechapikul W, Friedman JM, Lee TR. Well-ordered self-assembled monolayer surfaces can be used to enhance the growth of protein crystals. Colloid Surface B 2004; 34: 191-6.<\/li>\n
        • 2006<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, Taka T, Bethencourt M, Makonkawkeyoon L, Randall Lee T. The influence of pH on the G-quadruplex binding selectivity of perylene derivatives. Bioorg Med Chem Lett. 2006; 16: 4120-6.<\/li>\n
        • 2008<\/strong>\u00a0\u00a0\u00a0\u00a0Lee TC, Chen PC, Lai TY, Tuntiwechapikul W, Kim JH, Lee TR. Aliphatic dithiocarboxylic acids: New adsorbates for soft lithographic patterning. Applied Surface Science 2008; 254: 7064-8<\/li>\n
        • 2009<\/strong>\u00a0\u00a0\u00a0\u00a0Makonkawkeyoon L, Pharephan S, Tuntiwechapikul W, Makonkawkeyoon S. Application of Monoclonal and Polyclonal Antibodies to Hb Barts for the Detection of Thalassemias. The Open Hematology Journal 2009; 3, 11-7.<\/li>\n
        • 2009<\/strong>\u00a0\u00a0\u00a0\u00a0Pradupsri P, Loetchutinat C, Nuntasaen N, Meepowpan P, Tuntiwechapikul W, Pompimon P. Anticancer activities of styrylpyrone from the leaves and twigs of Goniothalamus maewongensis via cell cycle arrest. American Journal of Applied sciences 2009; 6, 2018-2<\/li>\n
        • 2010<\/strong>\u00a0\u00a0\u00a0\u00a0Makonkawkeyoon L, Pharephan S, Sirivatanapa P, Tuntiwechapikul W, Makonkawkeyoon S. Development of an ELISA strip for the detection of {alpha} thalassemias. Haematologica. 2010; 95, 338-9.<\/li>\n
        • 2010<\/strong>\u00a0\u00a0\u00a0\u00a0Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, Pompimon W, Lee TR. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. 2010; 13,1347-54.<\/li>\n
        • 2012<\/strong>\u00a0\u00a0\u00a0\u00a0Taka T, Joonlasak K, Huang L, Lee TR, Tam-Chang SW, Tuntiwechapikul W. Down-regulation of the human VEGF gene expression by perylene monoimide derivatives. Bioorg Med Chem Lett. 2012; 22, 518-22.<\/li>\n
        • 2012<\/strong>\u00a0\u00a0\u00a0\u00a0Nayyatip S, Thaichana P, Buayairaksa M, Tuntiwechapikul W, Meepowpan P, Nuntasaen N, Pompimon W. Aristolactam-type alkaloids from Orophea enterocarpa and their cytotoxicities. Int J Mol Sci. 2012; 13, 5010-8.<\/li>\n
        • 2013<\/strong>\u00a0\u00a0\u00a0\u00a0Taka T, Huang L, Wongnoppavich A, Tam-Chang SW, Lee TR, Tuntiwechapikul W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg Med Chem. 2013; 21, 883-90. (IF 2011 = 2.921)<\/li>\n
        • 2014<\/strong>\u00a0\u00a0\u00a0\u00a0Taka T, Changtam C, Thaichana P, Kaewtunjai N, Suksamrarn A, Lee TR, Tuntiwechapikul W. Curcuminoid derivatives enhance telomerase activity in an in vitro TRAP assay. Bioorg Med Chem Lett. 2014; 24: 5242-6.<\/li>\n
        • 2015<\/strong>\u00a0\u00a0\u00a0\u00a0Pharephan S, Intorasoot S, Tuntiwechapikul W, Makonkawkeyoon S, Makonkaw-keyoon L. Cloning and expression of a recombinant single-chain variable fragment antibody specific to Hemoglobin Bart\u0e42\u0e42\u0082\u0e0c\u0e22\u0099s. Asian Pac J Health Sci. 2015; 2: 28-35<\/li>\n<\/ul>\n

           <\/p>\n

          Books<\/h3>\n
            \n
          1. \u00a02013 \u0e15\u0e33\u0e23\u0e32\u0e2d\u0e13\u0e39\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32: \u0e42\u0e1b\u0e23\u0e15\u0e35\u0e19 \u0e22\u0e35\u0e19 \u0e41\u0e25\u0e30 \u0e14\u0e35\u0e40\u0e2d\u0e47\u0e19\u0e40\u0e2d ISBN: 978-616-335-671-0<\/li>\n<\/ol>\n

             <\/p>\n

            Training Fellowships<\/h3>\n
              \n
            • 2002.<\/strong>\u00a0\u00a0\u00a0\u00a0Postdoctoral training, Department of Chemistry, University of Houston, Texas, USA<\/li>\n<\/ul>\n

               <\/p>\n

              Research Grants<\/h3>\n
                \n
              • 2002<\/strong>\u00a0\u00a0\u00a0\u00a0Investigation of perylene derivatives with different charges and their telomerase inhibitory effect\u00a0\u00a0\u00a0\u00a0Faculty of Medicine Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0199,900 baht<\/li>\n
              • 2003<\/strong>\u00a0\u00a0\u00a0\u00a0Investigation of G-quadruplex-mediated telomerase inhibitors with selective cytotoxicity\u00a0\u00a0\u00a0\u00a0Thailand Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0480,000 baht<\/li>\n
              • 2007<\/strong>\u00a0\u00a0\u00a0\u00a0Studies of perylene derivatives and plant chemicals that Iihibit telomerase for anticancer therapy\u00a0\u00a0\u00a0\u00a0Thailand Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a01,200,000 baht<\/li>\n
              • 2007<\/strong>\u00a0\u00a0\u00a0\u00a0Finding telomerase inhibitors from medicinal plants to use as cancer chemotherapeutic agents\u00a0\u00a0\u00a0\u00a0National Research Council of Thailand\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a01,000,000 baht<\/li>\n
              • 2008<\/strong>\u00a0\u00a0\u00a0\u00a0Production of telomerase by transient expression of gene-containing plasmids for direct telomerase inhibition assay\u00a0\u00a0\u00a0\u00a0Faculty of Medicine Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0200,000 baht<\/li>\n
              • 2009<\/strong>\u00a0\u00a0\u00a0\u00a0Structural determination of anti-telomerase agents to use as cancer-specific chemotherapeutic agents\u00a0\u00a0\u00a0\u00a0National Research Council of Thailand\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0632,500 baht<\/li>\n
              • 2009<\/strong>\u00a0\u00a0\u00a0\u00a0Inhibition of vascular endothelial growth factor gene expression by perylene derivatives\u00a0\u00a0\u00a0\u00a0Faculty of Medicine Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0200,000 baht<\/li>\n
              • 2010<\/strong>\u00a0\u00a0\u00a0\u00a0Effects of perylene derivatives on telomere shortening and senescence in lung cancer cells\u00a0\u00a0\u00a0\u00a0Faculty of Medicine Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0200,000 baht<\/li>\n
              • 2011<\/strong>\u00a0\u00a0\u00a0\u00a0Activation of telomerase activity by curcuminoid derivatives\u00a0\u00a0\u00a0\u00a0Faculty of Medicine Research Fund\u00a0\u00a0\u00a0\u00a0Principal Investigator\u00a0\u00a0\u00a0\u00a0200,000 baht<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

                Wirote Tuntiwechapikul \u0e23\u0e28. \u0e14\u0e23.\u0e27\u0e34\u0e42\u0e23\u0e08\u0e19\u0e4c \u0e15\u0e31\u0e19\u0e15\u0e34\u0e40\u0e27\u0e0a\u0e2d\u0e20\u0e34\u0e01\u0e38\u0e25 Position\u00a0Associate Professor           Education 2001\u00a0 \u00a0 \u00a0 \u00a0 Doctor of Philosophy (Medicinal Chemistry), University of Texas at Austin, USA 1994\u00a0 \u00a0 \u00a0 \u00a0 Master of Science (Biochemistry), Faculty of Medicine, Chiang Mai University, Thailand 1988\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bachelor of Pharmacy, Chulalongkorn University, Thailand   Professional Experience 2002\u00a0\u00a0\u00a0\u00a0Lecturer 2004\u00a0\u00a0\u00a0\u00a0Assistant…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-155","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t