Wirote Tuntiwechapikul
รศ.ดร.วิโรจน์ ตันติเวชอภิกุล
Position Associate Professor
EMail wirotetunti@yahoo.com
Education
- 2001 Doctor of Philosophy (Medicinal Chemistry), University of Texas at Austin, USA
- 1994 Master of Science (Biochemistry), Faculty of Medicine, Chiang Mai University, Thailand
- 1988 Bachelor of Pharmacy, Chulalongkorn University, Thailand
Professional Experience
- 2002 Lecturer
- 2004 Assistant Professor
- 2014 Associate Professor
Research Interests
- Anticancer drugs based on telomerase inhibition
Publications
- 2001 Tuntiwechapikul W, Lee JT, Salazar M. Design and synthesis of the G-quadruplex-specific cleaving reagent Perylene-EDTA-Iron(II). J Am Chem Soc. 2001; 123: 5606-7.
- 2001 Tuntiwechapikul W, Salazar M. Cleavage of telomeric G-quadruplex DNA with Perylene-EDTA-Fe(II). Biochemistry 2001; 40: 13652-8.
- 2002 Tuntiwechapikul W, Salazar M. Mechanism of in-vitro expansion of long DNA repeats: effect of temperature, repeat length, and DNA polymerases. Biochemistry 2002; 41: 854-60.
- 2002 Tuntiwechapikul W, David WM, Kumar D, Kerwin SM, Salazar M. DNA modification by 4-Aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity. Biochemistry 2002; 41: 5283-90.
- 2002 Tuntiwechapikul W. Telomerase as a target for anticancer agents. Chiang Mai Med Bull. 2002; 41: 223-31.
- 2004 Pham T, Lai D, Ji D, Tuntiwechapikul W, Friedman JM, Lee TR. Well-ordered self-assembled monolayer surfaces can be used to enhance the growth of protein crystals. Colloid Surface B 2004; 34: 191-6.
- 2006 Tuntiwechapikul W, Taka T, Bethencourt M, Makonkawkeyoon L, Randall Lee T. The influence of pH on the G-quadruplex binding selectivity of perylene derivatives. Bioorg Med Chem Lett. 2006; 16: 4120-6.
- 2008 Lee TC, Chen PC, Lai TY, Tuntiwechapikul W, Kim JH, Lee TR. Aliphatic dithiocarboxylic acids: New adsorbates for soft lithographic patterning. Applied Surface Science 2008; 254: 7064-8
- 2009 Makonkawkeyoon L, Pharephan S, Tuntiwechapikul W, Makonkawkeyoon S. Application of Monoclonal and Polyclonal Antibodies to Hb Barts for the Detection of Thalassemias. The Open Hematology Journal 2009; 3, 11-7.
- 2009 Pradupsri P, Loetchutinat C, Nuntasaen N, Meepowpan P, Tuntiwechapikul W, Pompimon P. Anticancer activities of styrylpyrone from the leaves and twigs of Goniothalamus maewongensis via cell cycle arrest. American Journal of Applied sciences 2009; 6, 2018-2
- 2010 Makonkawkeyoon L, Pharephan S, Sirivatanapa P, Tuntiwechapikul W, Makonkawkeyoon S. Development of an ELISA strip for the detection of {alpha} thalassemias. Haematologica. 2010; 95, 338-9.
- 2010 Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, Pompimon W, Lee TR. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. 2010; 13,1347-54.
- 2012 Taka T, Joonlasak K, Huang L, Lee TR, Tam-Chang SW, Tuntiwechapikul W. Down-regulation of the human VEGF gene expression by perylene monoimide derivatives. Bioorg Med Chem Lett. 2012; 22, 518-22.
- 2012 Nayyatip S, Thaichana P, Buayairaksa M, Tuntiwechapikul W, Meepowpan P, Nuntasaen N, Pompimon W. Aristolactam-type alkaloids from Orophea enterocarpa and their cytotoxicities. Int J Mol Sci. 2012; 13, 5010-8.
- 2013 Taka T, Huang L, Wongnoppavich A, Tam-Chang SW, Lee TR, Tuntiwechapikul W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg Med Chem. 2013; 21, 883-90. (IF 2011 = 2.921)
- 2014 Taka T, Changtam C, Thaichana P, Kaewtunjai N, Suksamrarn A, Lee TR, Tuntiwechapikul W. Curcuminoid derivatives enhance telomerase activity in an in vitro TRAP assay. Bioorg Med Chem Lett. 2014; 24: 5242-6.
- 2015 Pharephan S, Intorasoot S, Tuntiwechapikul W, Makonkawkeyoon S, Makonkaw-keyoon L. Cloning and expression of a recombinant single-chain variable fragment antibody specific to Hemoglobin Bartโโฌยs. Asian Pac J Health Sci. 2015; 2: 28-35
Books
- 2013 ตำราอณูชีววิทยา: โปรตีน ยีน และ ดีเอ็นเอ ISBN: 978-616-335-671-0
Training Fellowships
- 2002. Postdoctoral training, Department of Chemistry, University of Houston, Texas, USA
Research Grants
- 2002 Investigation of perylene derivatives with different charges and their telomerase inhibitory effect Faculty of Medicine Research Fund Principal Investigator 199,900 baht
- 2003 Investigation of G-quadruplex-mediated telomerase inhibitors with selective cytotoxicity Thailand Research Fund Principal Investigator 480,000 baht
- 2007 Studies of perylene derivatives and plant chemicals that Iihibit telomerase for anticancer therapy Thailand Research Fund Principal Investigator 1,200,000 baht
- 2007 Finding telomerase inhibitors from medicinal plants to use as cancer chemotherapeutic agents National Research Council of Thailand Principal Investigator 1,000,000 baht
- 2008 Production of telomerase by transient expression of gene-containing plasmids for direct telomerase inhibition assay Faculty of Medicine Research Fund Principal Investigator 200,000 baht
- 2009 Structural determination of anti-telomerase agents to use as cancer-specific chemotherapeutic agents National Research Council of Thailand Principal Investigator 632,500 baht
- 2009 Inhibition of vascular endothelial growth factor gene expression by perylene derivatives Faculty of Medicine Research Fund Principal Investigator 200,000 baht
- 2010 Effects of perylene derivatives on telomere shortening and senescence in lung cancer cells Faculty of Medicine Research Fund Principal Investigator 200,000 baht
- 2011 Activation of telomerase activity by curcuminoid derivatives Faculty of Medicine Research Fund Principal Investigator 200,000 baht